AAPS PharmSciTech

, Volume 19, Issue 1, pp 36–47 | Cite as

Stability of Organoleptic Agents in Pharmaceuticals and Cosmetics

  • Akash Patil
  • Supriya Bhide
  • Mustafa Bookwala
  • Bhavik Soneta
  • Vijaykumar Shankar
  • Ahmed Almotairy
  • Mashan Almutairi
  • S. Narasimha MurthyEmail author
Mini-Review Theme: Stability of Pharmaceutical Excipients
Part of the following topical collections:
  1. Theme: Stability of Pharmaceutical Excipients


Organoleptic agents constitute an important niche in the field of pharmaceutical excipients. These agents encompass a range of additives responsible for coloring, flavoring, sweetening, and texturing formulations. All these agents have come to play a significant role in pharmaceuticals and cosmetics due to their ability to increase patient compliance by elevating a formulation’s elegance and esthetics. However, it is essential to review their physical and chemical attributes before use, as organoleptic agents, similar to active pharmaceutical ingredients (APIs), are susceptible to physical and chemical instability leading to degradation. These instabilities can be triggered by API-organoleptic agent interaction, exposure to light, air and oxygen, and changes in pH and temperature. These organoleptic agent instabilities are of serious concern as they affect API and formulation stability, leading to API degradation or the potential for manifestation of toxicity. Hence, it is extremely critical to evaluate and review the physicochemical properties of organoleptic agents before their use in pharmaceuticals and cosmetics. This literature review discusses commonly used organoleptic agents in pharmaceutical and cosmeceutical formulations, their associated instabilities, and probable approaches to overcoming them.


colors flavors sweeteners textures stability interaction 


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Copyright information

© American Association of Pharmaceutical Scientists 2017

Authors and Affiliations

  • Akash Patil
    • 1
  • Supriya Bhide
    • 1
  • Mustafa Bookwala
    • 1
  • Bhavik Soneta
    • 1
  • Vijaykumar Shankar
    • 1
  • Ahmed Almotairy
    • 1
  • Mashan Almutairi
    • 1
  • S. Narasimha Murthy
    • 1
    • 2
    Email author
  1. 1.Department of Pharmaceutics and Drug DeliveryUniversity of MississippiUniversityUSA
  2. 2.Institute for Drug Delivery and Biomedical ResearchBangaloreIndia

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