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DEM Modelling of Granule Rearrangement and Fracture Behaviours During a Closed-Die Compaction

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Abstract

The closed-die compaction behaviour of D-mannitol granules has been simulated by the discrete element method (DEM) to investigate the granule rearrangement and fracture behaviour during compaction which affects the compactibility of the tablet. The D-mannitol granules produced in a fluidized bed were modelled as agglomerates of primary particles connected by linear spring bonds. The validity of the model granule used in the DEM simulation was demonstrated by comparing to the experimental results of a uniaxial compression test. During uniaxial compression, the numerical results of the force-displacement curve corresponded reasonably well to the experimental data. The closed-die compaction of the modelled granules was carried out to investigate the rearrangement and fracture behaviours of the granule at different upper platen velocities. The forces during closed-die compaction calculated by DEM fluctuated in the low-pressure region due to the rearrangement of granules. A Heckel analysis showed that the force fluctuation occurred at the initial bending region of the Heckel plot, which represents the granule rearrangement and fracture. Furthermore, the upper platen velocity affected the trend of compaction forces, which can lead to compaction failure due to capping. These results could contribute to designing the appropriate granules during closed-die compaction.

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Authors and Affiliations

  1. Pharmaceutical Research Laboratories, Mitsubishi Tanabe Pharma Corporation, 3-16-89, Kashima, Yodogawa-ku, Osaka, 532-8505, Japan

    Ryoichi Furukawa & Tetsuro Noguchi

  2. Department of Chemical Engineering and Materials Science, Doshisha University, 1-3, Tatara Miyakodani, Kyotanabe, Kyoto, 610-0321, Japan

    Ryoichi Furukawa, Atsuko Shimosaka & Yoshiyuki Shirakawa

  3. Osaka University of Pharmaceutical Sciences, 4-20-1, Nasahara, Takatsuki, Osaka, 569-1094, Japan

    Kazunori Kadota

Authors
  1. Ryoichi Furukawa
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  2. Kazunori Kadota
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  3. Tetsuro Noguchi
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  4. Atsuko Shimosaka
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  5. Yoshiyuki Shirakawa
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Correspondence to Ryoichi Furukawa or Yoshiyuki Shirakawa.

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Furukawa, R., Kadota, K., Noguchi, T. et al. DEM Modelling of Granule Rearrangement and Fracture Behaviours During a Closed-Die Compaction. AAPS PharmSciTech 18, 2368–2377 (2017). https://doi.org/10.1208/s12249-017-0719-z

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