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Lipid- and Polymer-Based Nanostructures for Cutaneous Delivery of Curcumin

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Abstract

It is well-known that nanoencapsulation may overcome biopharmaceutical limitations of curcumin (CUR), but studies regarding the contribution of the vesicular nature of CUR-loaded nanoparticles on skin permeation are still scarce. Therefore, the effect of three colloidal systems (solid lipid nanoparticles (SLN), nanoemulsion (NE), and polymeric nanoparticles (NP)) on the control of cutaneous permeation of CUR was investigated in porcine ear skin/Franz diffusion cells. Colloidal suspensions were designed to present a similar particle size (±170 nm), narrow size distribution (PdI < 0.2), and high entrapment efficiency (>99%). Zeta potential values were −0.13, −9.68 and −36.7 mV for the CUR-loaded NP, SLN and NE, respectively. Nanoencapsulation resulted in a cumulative amount of CUR in the more superficial layers of the skin. NP significantly enhanced the compound retention in the epidermis, which was approximately 2.49- and 3.32-fold more than SLN and NE, respectively. The CUR levels into the dermis were significantly increased after treatment with NE, which may be associated with repulsion phenomena in surface skin. Therefore, a more superficial or deeper action of CUR on the skin may be obtained depending on nanostructure type. While NPs are more effective in upper skin layers, NE should be prioritized when a dermal action for the CUR is required.

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Acknowledgments

We would like to acknowledge CNPq/MCTI and CAPES/MEC (PNPD fellowship–001/2010) for the financial support. The authors are also grateful to the Laboratório Multiusuário de Estudos em Biologia (LAMEB/UFSC) for its technical assistance for the microscopic analyses and to the Mind the Graph team for granting us free access to its database, which was used to prepare the Graphical Abstract.

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Authors and Affiliations

  1. Laboratório de Controle de Qualidade, Programa de Pós-Graduação em Farmácia, Departamento de Ciências Farmacêuticas, Universidade Federal de Santa Catarina (UFSC), Campus Universitário, Trindade, 88040-900, Florianópolis, SC, Brazil

    Thiago Caon, Letícia Mazzarino & Marcos Antônio Segatto Silva

  2. Laboratório de Virologia Aplicada, Programa de Pós-Graduação em Farmácia, Departamento de Ciências Farmacêuticas, Universidade Federal de Santa Catarina (UFSC), Campus Universitário, Trindade, 88040-900, Florianópolis, SC, Brazil

    Cláudia Maria Oliveira Simões

  3. Laboratório de Farmacotécnica e Cosmetologia, Programa de Pós-Graduação em Farmácia, Departamento de Ciências Farmacêuticas, Universidade Federal de Santa Catarina (UFSC), Campus Universitário, Trindade, 88040-900, Florianópolis, SC, Brazil

    Thiago Caon & Elenara Lemos Senna

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  1. Thiago Caon
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Correspondence to Thiago Caon.

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Caon, T., Mazzarino, L., Simões, C.M.O. et al. Lipid- and Polymer-Based Nanostructures for Cutaneous Delivery of Curcumin. AAPS PharmSciTech 18, 920–925 (2017). https://doi.org/10.1208/s12249-016-0554-7

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  • DOI: https://doi.org/10.1208/s12249-016-0554-7

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