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Whey Protein/Polysaccharide-Stabilized Oil Powders for Topical Application—Release and Transdermal Delivery of Salicylic Acid from Oil Powders Compared to Redispersed Powders

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Abstract

Oil-in-water (o/w) emulsions are commonly converted into solid-like powders in order to improve their physical and chemical stabilities. The aim of this study was to investigate whether whey protein/polysaccharide-stabilized o/w emulsions could be converted into stable oil powders by means of freeze-drying. Moreover, during this study, the effects of pH and polymer type on release and trans(dermal) delivery of salicylic acid, a model drug, from these oil powders were investigated and compared to those of the respective template emulsions and redispersed oil powders. Physical characterization of the various formulations was performed, such as droplet size analysis and oil leakage, and relationships drawn with regards to release and trans(dermal) delivery. The experimental outcomes revealed that the oil powders could be redispersed in water without changing the release characteristics of salicylic acid. pH and polymer type affected the release of salicylic acid from the oil powders, template emulsions, and redispersed powders similarly. Contrary, the transdermal delivery from the oil powders and from their respective redispersed oil powders was differently affected by pH and polymer type. It was hypothesized that the release had been influenced by the electrostatic interactions between salicylic acid and emulsifiers, whereas the transdermal performance could have been determined by the particle or aggregate sizes of the formulations.

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Acknowledgments

The authors would like to thank the North-West University for funding this project and Prof. Jan du Preez for his support with the HPLC analyses.

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Authors and Affiliations

  1. Centre of Excellence for Pharmaceutical Sciences, North-West University, Private Bag X6001, Potchefstroom, 2520, South Africa

    Magdalena Kotzé, Anja Otto & Jeanetta du Plessis

  2. Chemical Resource Beneficiation, North-West University, Potchefstroom Campus, Potchefstroom, South Africa

    Anine Jordaan

Authors
  1. Magdalena Kotzé
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  2. Anja Otto
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  3. Anine Jordaan
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  4. Jeanetta du Plessis
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Correspondence to Anja Otto.

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Kotzé, M., Otto, A., Jordaan, A. et al. Whey Protein/Polysaccharide-Stabilized Oil Powders for Topical Application—Release and Transdermal Delivery of Salicylic Acid from Oil Powders Compared to Redispersed Powders. AAPS PharmSciTech 16, 835–845 (2015). https://doi.org/10.1208/s12249-014-0265-x

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  • DOI: https://doi.org/10.1208/s12249-014-0265-x

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