Synthesis of a Semi-Interpenetrating Polymer Network as a Bioactive Curcumin Film
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This study focused on the synthesis and characterization of a natural polymeric system employing the interpenetrating polymer network (IPN) comprising curcumin as a bioactive. Biopolymers and actives such as chitosan, hypromellose, citric acid, genipin, and curcumin were used to develop an effective, biodegradable, and biocompatible film employed therapeutically as a wound healing platform. The semi-IPN films were investigated for their physicochemical, physicomechanical, and biological properties by quantification by FTIR, DSC, and Young’s modulus. Following characterization, an optimum candidate formulation was produced whereby further in vitro and ex vivo studies were performed. Results revealed a burst release occurring at the first hour with 1.1 mg bioactive released when in contact with the dissolution medium and 2.23 mg due to bioactive permeation through the skin, thus suggesting that the lipophilic nature of skin greatly impacted the bioactive release rate. Furthermore, chemical and mechanical characterization and tensile strength analysis revealed that the degree of crosslinking and concentration of polymeric material used significantly influenced the properties of the film.
KEY WORDSbiomaterials crosslinker curcumin films semi-interpenetrating polymer network wound healing
This work was funded by the National Research Foundation (NRF) of South Africa.
Conflict of Interest
The Authors declare that there are no conflicts of interest.
- 6.Suzuki Y, Tanihara M, Nishmura Y, Suzuki K, Kakimara Y, Shimizu Y. A novel wound dressing with an antibiotic delivery system stimulated by microbial infection. ASA10 J. 1997;43:854–7.Google Scholar
- 39.Bindu TVL, Vidyavathi M, Kavitha K, Sastry TP, Suresh Kumar RV. Preparation and evaluation of chitosan-gelatin composite films for wound healing activity. Trends Biomater Artif Organs. 2010;24(3):123–30.Google Scholar
- 46.Bhuvaneshwari S, Sruthi D, Sivasubramanian V, Niranjana K, Sugunabai J. Development and characterization of chitosan films. Int J Eng Res and Appl (IJERA). 2000;1(2):292–9.Google Scholar
- 55.Scheuplein RJ. Permeability of the skin. Handbook of physiology, Reactions to environmental agents. 2011; doi: 10.1002/cphy.cp090119.
- 57.Rana V, Babita K, Goyal D, Tiwary AK. Soduim citrate crosslinked chitosan films: optimisation and substitute for human/rat/rabbit epidermal sheets. J Pharm Pharmaceut Sci. 2005;8(1):10–7.Google Scholar