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Aerodynamic and Electrostatic Properties of Model Dry Powder Aerosols: a Comprehensive Study of Formulation Factors

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  • Theme: Advances in Formulation and Device Technologies for Pulmonary Drug Delivery
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ABSTRACT

The impact of formulation variables on aerodynamic and electrostatic properties of dry powder aerosol particles is of great importance to the development of efficient and reproducible inhaler products. Systematic evaluation requires a well-designed series of experiments using appropriate methods. A factorial experimental design was employed. In broad terms, the conditions considered were two drugs, albuterol and budesonide, in combination with different excipients, drug concentrations, delivered doses, and metering system (capsule composition) and sampled under different flow conditions using standard entrainment tubes. Samples were collected in an electrical low-pressure impactor, to evaluate distribution of electrostatic properties, and an Andersen eight-stage nonviable cascade impactor, to estimate aerodynamic particle size distribution, concurrently. The deposition studies allowed calculation of approximate per particle charge levels for drug. The results showed very high particle charge levels, often in the 1,000–10,000 of elementary charges per particle range, orders of magnitude higher than charge levels predicted by the Boltzmann charge distribution. The charge levels are considerably higher than had previously been estimated (200e per particle).

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Acknowledgments

Dr. Chris Wiesen, Statistical Consultant at the UNC Odum Institute, is gratefully acknowledged for valuable discussions of the experimental design and help with the analysis. M. Telko gratefully acknowledges the financial support from a U.S. Pharmacopeia Fellowship and PhRMA Foundation Predoctoral fellowship during the completion of this work.

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Author notes

  1. M. J. Telko

    Present address: Novartis Animal Health, Basel, Switzerland

  2. A. J. Hickey

    Present address: RTI International, Research Triangle Park, North Carolina, 27709, USA

Authors and Affiliations

  1. Division of Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, 27599-7571, USA

    M. J. Telko & A. J. Hickey

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  1. M. J. Telko
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  2. A. J. Hickey
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Correspondence to A. J. Hickey.

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Guest Editors: Paul B. Myrdal and Steve W. Stein

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Telko, M.J., Hickey, A.J. Aerodynamic and Electrostatic Properties of Model Dry Powder Aerosols: a Comprehensive Study of Formulation Factors. AAPS PharmSciTech 15, 1378–1397 (2014). https://doi.org/10.1208/s12249-014-0144-5

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  • DOI: https://doi.org/10.1208/s12249-014-0144-5

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