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New Direct Compression Excipient from Tigernut Starch: Physicochemical and Functional Properties

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Abstract

Tigernut starch has been isolated and modified by forced retrogradation of the acidic gel by freezing and thawing processes. Relevant physicochemical and functional properties of the new excipient (tigernut starch modified by acid gelation and accelerated (forced) retrogradation (STAM)) were evaluated as a direct compression excipient in relation to the native tigernut starch (STNA), intermediate product (tigernut starch modified by acid gelation (STA)), and microcrystalline cellulose (MCC). The particle morphology, swelling capacity, moisture sorption, differential scanning calorimeter (DSC) thermographs and X-ray powder diffraction (XRD) patterns, flow, dilution capacity, and tablet disintegration efficiency were evaluated. The particles of STNA were either round or oval in shape, STA were smooth with thick round edges and hollowed center while STAM were long, smooth, and irregularly shaped typically resembling MCC. The DSC thermographs of STNA and MCC showed two endothermic transitions as compared with STA and STAM which showed an endothermic and an exothermic. The moisture uptake, swelling, flow, and dilution capacity of STAM were higher than those of MCC, STA, and STNA. The XRD pattern and moisture sorption profile of STAM showed similarities and differences with STNA, STA, and MCC that relate the modification. Acetylsalicylic acid (ASA) tablets containing STAM disintegrated at 3 ± 0.5 min as compared with the tablets containing STNA, STA, and MCC which disintegrated at 8.5 ± 0.5, 10 ± 0.5, and 58 ± 0.8 min, respectively. The study shows the physicochemical properties of tigernut starch modified by forced retrogradation as well as its potential as an efficient direct compression excipient with enhanced flow and disintegration abilities for tablets production.

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Abbreviations

STNA :

Native tigernut starch

STA :

Tigernut starch modified by acid gelation

STAM :

Tigernut starch modified by acid gelation and accelerated (forced) retrogradation

MCC:

Microcrystalline cellulose

Apn:

Acetaminophen

ASA:

Acetyls alicylic acid

SEM:

Scanning electron micrograph

RH:

Relative humidity

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Authors and Affiliations

  1. Department of Pharmaceutical Technology and Raw Materials Development, National Institute for Pharmaceutical Research and Development, Abuja, Nigeria

    Philip F. Builders, Patricia A. Anwunobi & Chukwuemeka C. Mbah

  2. Department of Pharmaceutics, University of Nigeria, Nsukka, 410001, Enugu State, Nigeria

    Michael U. Adikwu

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  1. Philip F. Builders
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  4. Michael U. Adikwu
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Correspondence to Philip F. Builders.

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Builders, P.F., Anwunobi, P.A., Mbah, C.C. et al. New Direct Compression Excipient from Tigernut Starch: Physicochemical and Functional Properties. AAPS PharmSciTech 14, 818–827 (2013). https://doi.org/10.1208/s12249-013-9968-7

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