AAPS PharmSciTech

, Volume 15, Issue 2, pp 279–286 | Cite as

Evaluation of Citrus Fibers as a Tablet Excipient

  • Marco Cespi
  • Giulia Bonacucina
  • Matthew Roberts
  • Samuel Hanson
  • Stephen Jones
  • Elina Makevica
  • Luca Casettari
  • Giovanni Filippo Palmieri
Research Article


The consumption of fibers is associated with many health benefits, such as a reduction of cardiovascular and gastrointestinal diseases, control of body weight, and prevention of diabetes. Despite the widespread use of fiber supplements such as capsules or tablets, there is an almost complete lack of information concerning the technological properties of functional fibers used in nutraceutical formulations. The aim of this work was to characterize the technological properties of citrus fibers necessary for their use as a processing aid in tableting. The results obtained showed that citrus fibers share many properties of other polysaccharides used as tableting excipients, such as thermal behavior and compaction mechanism, together with an appreciable tabletability. However, the most interesting properties resulted from their disintegration power. Citrus fibers behaved in a similar manner to the well-known super disintegrant croscarmellose sodium and resulted to be little susceptible to their concentration, to lubricant type, and lubricant concentration. Thus, this work supports the idea of a potential use of citrus fibers as “active” substances and processing aid in the tableting of nutraceutical products and also as functional excipient in pharmaceutical tablets formulation.


citrus fibers disintegration Heckel analysis tabletability thermal analysis 

Supplementary material

12249_2013_59_MOESM1_ESM.doc (130 kb)
ESM 1 (DOC 130 kb)


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Copyright information

© American Association of Pharmaceutical Scientists 2013

Authors and Affiliations

  • Marco Cespi
    • 1
  • Giulia Bonacucina
    • 1
  • Matthew Roberts
    • 2
  • Samuel Hanson
    • 2
  • Stephen Jones
    • 2
  • Elina Makevica
    • 2
  • Luca Casettari
    • 3
  • Giovanni Filippo Palmieri
    • 1
  1. 1.University of Camerino, School of PharmacyCamerinoItaly
  2. 2.Liverpool John Moores University, School of Pharmacy and Biomolecular SciencesLiverpoolUK
  3. 3.University of Urbino “Carlo Bo”, Department of Biomolecular SciencesUrbinoItaly

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