The Experimental Evaluation and Molecular Dynamics Simulation of a Heat-Enhanced Transdermal Delivery System
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Transdermal delivery systems are useful in cases where preferred routes such as the oral route are not available. However, low overall extent of delivery is seen due to the permeation barrier posed by the skin. Chemical penetration enhancers and invasive methods that disturb the structural barrier function of the skin can be used to improve transdermal drug delivery. However, for suitable drugs, a fast-releasing transdermal delivery system can be produced by incorporating a heating source into a transdermal patch. In this study, a molecular dynamics simulation showed that heat increased the diffusivity of the drug molecules, resulting in faster release from gels containing ketoprofen, diclofenac sodium, and lidocaine HCl. Simulations were confirmed by in vitro drug release studies through lipophilic membranes. These correlations could expand the application of heated transdermal delivery systems for use as fast-release-dosage forms.
KEY WORDSdiffusion heated patch ketoprofen molecular dynamics transdermal
- 22.Nuvo Research Inc. (2012) Controlled heat-assisted drug delivery (CHADD™) technology. http://www.nuvoresearch.com/research/chadd.htm. Accessed 16 August 2012.
- 23.Accelrys Software Inc. Materials Studio® 6.0 (2012) Accelrys Software Inc. San Diego, USA. http://www.accelrys.com. Accessed 04 June 2012.
- 39.BASF (2012) Technical bulletin. Pluronics® F127 block copolymer surfactant. Available from: http://worldaccount.basf.com/wa/NAFTA/Catalog/ChemicalsNAFTA/doc4/BASF/PRD/30089187. Accessed 16 August 2012.
- 43.Liebenberg W, Engelbrecht E, Wessels A, Devarakonda B, Yang W, de Villiers MM. A comparative study of the release of active ingredients from semi-solid cosmeceuticals measured with a Franz, enhancer or flow-through cell diffusion apparatus. J Food Drug Anal (Yaowu Shipin Fenxi). 2004;12:19–28.Google Scholar
- 44.Tanaka K. Self-diffusion coefficients of water in pure water and in aqueous solutions of several electrolytes with 18O and 2H as tracers. J Chem Soc Faraday Trans 1 Phys Chem Condensed Phases. 1978;74:1879–81.Google Scholar
- 45.Arrhenius S. On the reaction velocity of the inversion of cane sugar by acids. Z Phys Chem. 1889;4:226.Google Scholar