Abstract
Currently available information on drug lithiasis usually describes the calculi based on the prescriptions given to the patient, but without a physicochemical characterization of the calculi themselves. We here have applied different, complementary, physicochemical techniques for a complete characterization of an unusual urolithiasis calculus. The calculus was characterized using powder X-ray diffraction, infrared spectroscopy, mass spectrometry, 1H-NMR spectroscopy, and scanning electron microscopy. The precise nature of the calculus was identified, being formed by N4-acetylsulfadiazine, so being related to the drugs prescribed to the patient. Analytical techniques widely used in laboratories of Materials Chemistry have proven to be useful tools for characterizing the chemical nature of unusual urolithiasis.
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Cuervo, C., González, J., Rives, V. et al. Characterization of a Sulfadiazine-Induced Lithiasis Calculus by Physicochemical Techniques. AAPS PharmSciTech 14, 128–132 (2013). https://doi.org/10.1208/s12249-012-9892-2
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DOI: https://doi.org/10.1208/s12249-012-9892-2