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Practical Considerations in the Measurement of the Internal Relative Humidity of Pharmaceutical Packages with Data Loggers

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Abstract

The utility of temperature/humidity data loggers are evaluated as a low-cost approach to enrich practical understanding of the actual time dependent humidity that a pharmaceutical product is exposed to. While this approach is found to have significant utility in general, small systematic biases in the measurements due to the presence of the data logger are observed. Taking these biases into account enables more productive extrapolation of measured time/humidity profiles.

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ACKNOWLEDGMENTS

Dr. Rajiv Mahajan and Dr. Rey Chern are thanked for many hours of helpful discussion of the underlying technical significance of water activity and packaging science. Prof. Carl Nelson is thanked for thoughtful feedback and input into the theoretical background discussed in this manuscript.

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Authors and Affiliations

  1. Johnson & Johnson Pharmaceutical Research and Development, Raritan, New Jersey, 08869, USA

    Eric D. Nelson & Henry Huang

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  1. Eric D. Nelson
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  2. Henry Huang
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Correspondence to Eric D. Nelson.

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Nelson, E.D., Huang, H. Practical Considerations in the Measurement of the Internal Relative Humidity of Pharmaceutical Packages with Data Loggers. AAPS PharmSciTech 12, 331–336 (2011). https://doi.org/10.1208/s12249-011-9588-z

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  • DOI: https://doi.org/10.1208/s12249-011-9588-z

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