Skip to main content
SpringerLink
Log in

Measuring Surface Roughness of Pharmaceutical Powders Using Vapor Sorption Methods

  • Brief/Technical Note
  • Published:
AAPS PharmSciTech Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5

References

  1. Healy AM, Corrigan OI, Allan JEM. The effect of dissolution on the surface texture of model solid-dosage forms as assessed by non-contact laser profilometry. Pharm Technol Eur. 1995;9:14–22.

    Google Scholar 

  2. Podczeck F. Measurement of surface roughness of tablets made from polyethylene glycol powders of various molecular weight. Pharm Pharmacol Commun. 1998;4:179–82.

    CAS  Google Scholar 

  3. Riipi M, Antikainen O, Niskanen T, Yliruusi J. The effect of compression force on surface structure, crushing strength, friability and disintegration time of erythromycin acistrate tablets. Eur J Pharm Biopharm. 1998;46:339–45.

    Article  Google Scholar 

  4. Felton L, McGinity JW. Adhesion of polymeric films to pharmaceutical solids. Eur J Pharm Biopharm. 1999;47:3–14.

    Article  PubMed  CAS  Google Scholar 

  5. Missaghi S, Fassihi R. A novel approach in the assessment of polymeric film formation and film adhesion on different pharmaceutical solid substrates. AAPS PharmSciTech. 2004;5:E29.

    Article  PubMed  Google Scholar 

  6. Reiland TL, Eber AC. Aqueous gloss solutions: formula and process variables effects on the surface texture of film coated tablets. Drug Dev Ind Pharm. 1986;12:213–45.

    Article  Google Scholar 

  7. Rohera BD, Parikh NH. Influence of plasticizer type and coat level on Surelease film properties. Pharm Dev Technol. 2002;7:407–20.

    Article  PubMed  CAS  Google Scholar 

  8. Ferrair F, Cocconi D, Bettini R, Giordano F, Santi P, Tobyn M, Price R, Young P, Caramella C, and Colombo P (2004) The surface roughness of lactose particles can be modulated by wet-smoothing using a high-shear mixer. AAPS PharmSciTech. 5:Article 60

  9. Bell J (1994) Dry powder inhalation technology. Pharm. Manufact. Int. 179–182

  10. Prime D, Atkins PJ, Slater A, Sumby B. Review of dry powder inhalers. Adv Drug Deliv Rev. 1997;26:51–8.

    Article  PubMed  CAS  Google Scholar 

  11. Podczeck F. The relationship between particulate properties of carrier materials and the adhesion force of drug particles in interactive powder mixtures. J Adhes Sci Technol. 1997;11:1089–104.

    Article  CAS  Google Scholar 

  12. Podczeck F. Adhesion forces in interactive powder mixtures of a micronized drug and carrier particles of various particle size distributions. J Adhes Sci Technol. 1998;12:1323–39.

    Article  CAS  Google Scholar 

  13. Flament M-P, Leterme P, Gayot A. The influence of carrier roughness on adhesion, content uniformity and the in vitro deposition of terbutaline sulphate from dry powder inhalers. Int J Pharm. 2004;275:201–9.

    Article  PubMed  CAS  Google Scholar 

  14. Podczeck F. The influence of particle size distribution and surface roughness of carrier particles on the in vitro properties of dry powder inhalations. Aerosol Sci Technol. 1999;31:301–21.

    Article  CAS  Google Scholar 

  15. Iida K, Hayakawa Y, Okomoto H, Danjo K, Leunberger H. Effect of surface layering time of lactose carrier particles on dry powder inhalation properties of salbutamol sulfate. Chem Pharm Bull. 2004;52:350–3.

    Article  PubMed  CAS  Google Scholar 

  16. Kawashima Y, Serigano T, Hino T, Yamamoto H, Takeuchi H. Effect of surface morphology of carrier lactose on dry powder inhalation property of pranlukast hydrate. Int J Pharm. 1998;172:179–88.

    Article  CAS  Google Scholar 

  17. Young PM, Cocconi D, Colombo P, Bettini R, Price R, Steele DF, et al. Characterization of a surface modified dry powder inhalation carrier prepared by ‘particle smoothing’. J Pharm Pharmacol. 2002;54:1339–44.

    Article  PubMed  CAS  Google Scholar 

  18. Iida K, Inagaki Y, Todo H, Okamoto H, Danjo K, Leunberger H. Effects of surface processing of lactose carrier particles on dry powder inhalation properties of salbutamol sulfate. Chem Pharm Bull. 2004;52:938–42.

    Article  PubMed  CAS  Google Scholar 

  19. Orafai H, Spring M. Roughness model for adhesion testing of pharmaceutical coating materials. Iran J Basic Med Sciences. 2007;10:124–31.

    CAS  Google Scholar 

  20. Avnir D, Farin D, Pfeifer P. Molecular fractal surfaces. Nature. 1984;308:261–3.

    Article  CAS  Google Scholar 

  21. Suzuki T, Yano T. Fractal structure analysis of some food materials. Agric Biol Chem. 1990;54(12):3131–5.

    CAS  Google Scholar 

  22. Kaneko K, Sato M, Suzuki T, Fujiwara Y, Nishikawa K, Jaroniec M. Surface fractal dimension of microporous carbon fibres by nitrogen adsorption. J Chem Soc Faraday Trans. 1991;87(1):179–84.

    Article  CAS  Google Scholar 

  23. Pettit FK, Bowie JU. Protein surface roughness and small molecular binding sites. J Mol Biol. 1999;285:1377–82.

    Article  PubMed  CAS  Google Scholar 

  24. Pfeifer P, Anvir D. Chemistry in noninteger dimensions between two and three. I. Fractal theory of heterogeneous surfaces. J Chem Phys. 1983;79:3558–65.

    Article  CAS  Google Scholar 

  25. Brunauer S, Emmett PH, Teller E. Adsorption of gases in multimolecular layers. J Am Chem Soc. 1938;60:309–19.

    Article  CAS  Google Scholar 

  26. Zhang Y, Law Y, Chakrabarti S (2003) Physical properties and compact analysis of commonly used direct compression binders. AAPS PharmSciTech. 4:Article 62.

  27. Johnton CT, Wang S-L, Hem SL. Measuring the surface area of aluminum hydroxide adjuvant. J Pharm Sci. 2002;91(7):1702–6.

    Article  Google Scholar 

  28. Chlou CT, Rutherford DW. Sorption of N2 and EGME vapors on some soils, clays, and mineral oxides and determination of sample surface areas by use of sorption data. Environ Sci Technol. 1993;27(8):1587–94.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Surface Measurement Systems Ltd, 2125 28th Street SW, Suite 1, Allentown, Pennsylvania, 18103, USA

    Daniel J. Burnett & Armando R. Garcia

  2. Department of Chemical Engineering, Imperial College London, London, UK

    Jerry Y. Y. Heng

  3. Novartis Horsham Research Centre, West Sussex, UK

    Frank Thielmann

  4. Surface Measurement Systems, Alperton, UK

    Majid Naderi & Manaswini Acharya

Authors
  1. Daniel J. Burnett
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Jerry Y. Y. Heng
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Frank Thielmann
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Armando R. Garcia
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Majid Naderi
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Manaswini Acharya
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Daniel J. Burnett.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Burnett, D.J., Heng, J.Y.Y., Thielmann, F. et al. Measuring Surface Roughness of Pharmaceutical Powders Using Vapor Sorption Methods. AAPS PharmSciTech 12, 56–61 (2011). https://doi.org/10.1208/s12249-010-9571-0

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1208/s12249-010-9571-0

KEY WORDS

Search

Navigation