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Improved Albendazole Dissolution Rate in Pluronic 188 Solid Dispersions

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Abstract

Solids dispersions (SDs) have been proposed as an alternative to improve the dissolution rate of low solubility drugs. SDs containing albendazole (ABZ; 5, 10, 25, and 50% w/w) and Pluronic 188 (P 188) as hydrophilic carrier were formulated. The obtained SDs were assessed in comparison to physical mixtures (PMs). Drug–polymer interactions in solid state were investigated using Fourier-transform infrared spectroscopy, scanning electron microscopy, and X-ray diffraction analysis. No chemical interaction was found between ABZ and poloxamer. The dissolution profiles indicated that ABZ incorporated in SDs and PMs was rapidly released, reaching rapidly the steady state. Increased dissolution rates are usually observed at the highest polymer proportions. However, an opposite effect for SDs as well as for PMs was observed in the assays described here. The systems with the lowest P 188 percentages (SD4, SD3; PM4, PM3) tended to be more effective in increasing the ABZ dissolution rate. Such a result can be attributed to the fact that concentrated aqueous solutions of Poloxamer may form thermo-reversible gels. The physical–mechanical properties indicated that SDs possess improved flow and compacting properties compared to PMs. Thus, ABZ SDs would be more convenient for solid dosage form design and manufacture.

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Acknowledgments

This work was supported by a grant of the Consejo Nacional de Investigaciones Cientificas y Técnicas de la República Argentina (CONICET). Silvina Castro has a fellowship of CONICET.

The authors especially thank Dario O. Weitmann, Business Coordinator BCS in BASF Argentina S.A for the Poloxamer samples.

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Authors and Affiliations

  1. Departamento de Farmacia, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Argentina, CONICET

    Silvina G. Castro, Daniel A. Allemandi & Santiago D. Palma

  2. Laboratorio de Farmacología, Facultad de Ciencias Veterinarias, UNCPBA-Tandil (7000), Argentina, CONICET

    Sergio Sanchez Bruni & Carlos E. Lanusse

Authors
  1. Silvina G. Castro
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  2. Sergio Sanchez Bruni
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  3. Carlos E. Lanusse
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  4. Daniel A. Allemandi
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  5. Santiago D. Palma
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Corresponding author

Correspondence to Santiago D. Palma.

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Castro, S.G., Bruni, S.S., Lanusse, C.E. et al. Improved Albendazole Dissolution Rate in Pluronic 188 Solid Dispersions. AAPS PharmSciTech 11, 1518–1525 (2010). https://doi.org/10.1208/s12249-010-9517-6

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  • DOI: https://doi.org/10.1208/s12249-010-9517-6

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