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Development and Evaluation of Emulsions from Carapa guianensis (Andiroba) Oil

AAPS PharmSciTech volume 11, pages 1383–1390 (2010)Cite this article

Abstract

Carapa guianensis, a popular medicinal plant known as “Andiroba” in Brazil, has been used in traditional medicine as an insect repellent and anti-inflammatory product. Additionally, this seed oil has been reported in the literature as a repellent against Aedes aegypti. The aim of this work is to report on the emulsification of vegetable oils such as “Andiroba” oil by using a blend of nonionic surfactants (Span 80® and Tween 20®), using the critical hydrophilic–lipophilic balance (HLB) and pseudo-ternary diagram as tools to evaluate the system’s stability. The emulsions were prepared by the inverse phase method. Several formulations were made according to a HLB spreadsheet design (from 4.3 to 16.7), and the products were stored at 25°C and 4°C. The emulsion stabilities were tested both long- and short-term, and the more stable one was used for the pseudo-ternary diagram study. The emulsions were successfully obtained by a couple of surfactants, and the HLB analysis showed that the required HLB of the oil was 16.7. To conclude, the pseudo-ternary diagram identified several characteristic regions such as emulsion, micro-emulsion, and separation of phases.

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ACKNOWLEDGEMENTS

The authors are grateful for the financial support received from CNPq (477131/2007-7), FAPERN/MCT/CT-INFRA/CNPq (PPP 2007), and UFRN (Propesq/Pibic). The authors also thank Glenn Hawes, from the University of Georgia—American Language Program, for his editing this manuscript.

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Affiliations

  1. Departamento de Farmácia—Centro de Ciências da Saúde, Universidade Federal do Rio Grande do Norte—UFRN, Av. Coronel Gustavo Cordeiro de Farias, s/n, Petrópolis, 59010-180, Natal, Rio Grande do Norte, Brazil

    Magda R. A. Ferreira, Rosilene R. Santiago & Eryvaldo S. T. Egito

  2. Departamento de Medicamentos e Alimentos, Universidade Federal do Amazonas—UFAM, Rua Alexandre Amorim 330, Aparecida, 69010-300, Manaus, Amazonas, Brazil

    Tatiane P. de Souza

  3. Centro de Ciências Biológicas e Sociais Aplicadas, Universidade Estadual da Paraíba—UEPB, Rua Monsenhor Valfredo Leal, 458, Tambia, 58058-420, João Pessoa, Paraíba, Brazil

    Elquio E. Oliveira

  4. Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Rio Grande do Norte—UFRN, Av. Coronel Gustavo Cordeiro de Farias, s/n, Petrópolis, 59010-180, Natal, Rio Grande do Norte, Brazil

    Tatiane P. de Souza, Eryvaldo S. T. Egito & Luiz A. L. Soares

  5. Departamento de Ciências Farmacêuticas, Universidade Federal de Pernambuco—UFPE, Rua Prof. Artur de Sá s/n, 50740-521, Recife, Pernambuco, Brazil

    Luiz A. L. Soares

Authors
  1. Magda R. A. Ferreira
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  2. Rosilene R. Santiago
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  5. Elquio E. Oliveira
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Correspondence to Luiz A. L. Soares.

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Ferreira, M.R.A., Santiago, R.R., de Souza, T.P. et al. Development and Evaluation of Emulsions from Carapa guianensis (Andiroba) Oil. AAPS PharmSciTech 11, 1383–1390 (2010). https://doi.org/10.1208/s12249-010-9491-z

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  • DOI: https://doi.org/10.1208/s12249-010-9491-z

KEY WORDS

  • Carapa guianensis oil
  • emulsions
  • hydrophilic–lipophilic balance (HLB)
  • pseudo-ternary diagram
  • stability