Abstract
Polymeric coating materials have been widely used to modify release rate of drug. We compared physical properties and release-controlling efficiency of polymeric coating materials using matrix-type casted film and diffusion-controlled coated tablet. Hydroxypropylmethyl cellulose (HPMC) with low or high viscosity grade, ethylcellulose (EC) and Eudragit® RS100 as pH-independent polymers and Eudragit S100 for enteric coatings were chosen to prepare the casted film and coated tablet. Tensile strength and contact angle of matrix-type casted film were invariably in the decreasing order: EC> Eudragit S100> HPMC 100000> Eudragit RS100>HPMC 4000. There was a strong linear correlation between tensile strength and contact angle of the casted films. In contrast, weight loss (film solubility) of the matrix-type casted films in three release media (gastric, intestinal fluid and water) was invariably in the increasing order: EC < HPMC 100000 < Eudragit RS100 < HPMC 4000 with an exception of Eudragit S100. The order of release rate of matrix-type casted films was EC > HPMC 100000 > Eudragit RS100 > HPMC 4000 > Eudragit S100. Interestingly, diffusion-controlled coated tablet also followed this rank order except Eudragit S100 although release profiles and lag time were highly dependent on the coating levels and type of polymeric coating materials. EC and Eudragit RS100 produced sustained release while HPMC and Eudragit S100 produced pulsed release. No molecular interactions occurred between drug and coating materials using 1H-NMR analysis. The current information on release-controlling power of five different coating materials as matrix carrier or diffusion-controlled film could be applicable in designing oral sustained drug delivery.
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Acknowledgments
This work was supported by the Korea Science and Engineering Foundation (KOSEF- R01-2008-000-11777-0), and by a grant of the 2009 Korean Health Technology R&D Project, Ministry for Health, Welfare & Family Affairs, Korea. The authors are grateful to Mr. Kyu-Yeol Nam for his partial contributions to the experiments. We also thank the Central Research Laboratory for the use of the 1H-NMR and the Research Institute of Pharmaceutical Sciences, Kangwon National University for allowing the use of their UV–Vis spectrometer.
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Piao, ZZ., Lee, KH., Kim, DJ. et al. Comparison of Release-Controlling Efficiency of Polymeric Coating Materials Using Matrix-type Casted Films and Diffusion-Controlled Coated Tablet. AAPS PharmSciTech 11, 630–636 (2010). https://doi.org/10.1208/s12249-010-9377-0
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DOI: https://doi.org/10.1208/s12249-010-9377-0