Abstract
The purpose of this study was to formulate a superporous hydrogel (SPH) containing carvedilol self-nanoemulsifying drug delivery system. Effects of formulation parameters (amount of SPH and 0.1 N HCl used during drug loading) were studied in 32 factorial design. Response surface plots showed significant effect of the parameters on hydrogel swelling, carvedilol content, and carvedilol in vitro release. Regression equations were generated to calculate the desirable responses.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Peppas NA, Mikos AG. Hydrogels in medicine and pharmacy. Boca Raton: CRC; 1986.
Park K. Superporous hydrogels for pharmaceutical & other applications; 2002. http://www.drugdeliverytech.com/cgi-bin/articles.cgi?idArticle=60.
Kroupova J, Horak D, Pachernik J, Dvorak P, Slouf M. Functional polymer hydrogels for embryonic stem cell support. J Biomed Mater Res B Appl Biomater. 2006;76(2):315–25.
Dorkoosh FA, Broekhuizen CA, Borchard G, Rafiee-Tehrani M, Verhoef JC, Junginger HE. Transport of octreotide and evaluation of mechanism of opening the paracellular tight junctions using superporous hydrogel polymers in Caco-2 cell monolayers. J Pharm Sci. 2004;93(3):743–52.
Ratner BD, Hoffman AS. Synthetic hydrogels for biomedical applications. Washington: American Chemical Society; 1976.
Omidian H, Rocca JG, Park K. Elastic, superporous hydrogel hybrids of polyacrylamide and sodium alginate. Macromol Biosci. 2006;6(9):703–10.
Kabra BG, Gehrke SH. Rate-limiting steps for solvent sorption and desorption by microporous stimuli-sensitive absorbent gels. Washington: American Chemical Society; 1994.
Chen J, Park H, Park K. Synthesis of superporous hydrogels: hydrogels with fast swelling and superabsorbent properties. J Biomed Mater Res. 1999;44(1):53–62.
Qiu Y, Park K. Superporous IPN hydrogels having enhanced mechanical properties. AAPS PharmSciTech. 2003;4(4):E51.
Chen J, Park K. Synthesis and characterization of superporous hydrogel composites. J Control Release. 2000;65(1–2):73–82.
Di Colo G, Baggiani A, Zambito Y, Mollica G, Geppi M, Serafini MF. A new hydrogel for the extended and complete prednisolone release in the GI tract. Int J Pharm. 2006;310(1–2):154–61.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Mahmoud, E.A., Bendas, E.R. & Mohamed, M.I. Effect of Formulation Parameters on the Preparation of Superporous Hydrogel Self-Nanoemulsifying Drug Delivery System (SNEDDS) of Carvedilol. AAPS PharmSciTech 11, 221–225 (2010). https://doi.org/10.1208/s12249-009-9359-2
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1208/s12249-009-9359-2