References
Brogden RN, Heel RC, Speight TM, Avery GS. Piroxicam: a reappraisal of its pharmacology and therapeutic efficacy. Drugs. 1984;28:292–323.
O'Hanlon JJ, Muldoon T, Lowry D, McCleane G. Improved postoperative analgesia with preoperative piroxicam. Can J Anaesth. 1996;43:102–5.
Lindhart RJ. Biodegradable polymers for controlled release of drugs. In: Rosoff M, editor. Controlled release of drugs: polymers and aggregate systems. New York: VCH; 1989. p. 53–95.
Burgess DJ, Hickey AJ. Microsphere technology and applications. In: Swarbrick J, Boylan JC, editors. Encyclopedia of pharmaceutical technology. New York: Marcel Dekker; 1994. p. 1–29.
Lemaire V, Belair J, Hildgen P. Structural modeling of drug release from biodegradable porous matrices based on a combined diffusion/erosion process. Int J Pharm. 2003;258:95–107.
Park TG. Degradation of poly(D, L-lactic acid) microspheres: effect of molecular weight. J Control Release. 1994;30:161–73.
Park TG. Degradation of poly(lactic-co-glycolic acid) microspheres: effect of copolymer composition. Biomaterials. 1995;16:1123–30.
Ramirez L, Pastoriza P, Herrero-Vanrell R. Biodegradable poly(DL lactic-co-glycolic acid) microspheres containing tetracaine hydrochloride: in-vitro release profile. J Microencapsul. 1999;16:105–15.
Miyajima M, Koshika A, Okada J, Ikeda M. Mechanism of drug release from poly(L-lactic acid) matrix containing acidic or neutral drugs. J Control Release. 1999;60:199–209.
Miyajima M, Koshika A, Okada J, Ikeda M. Effect of polymer/basic drug interactions on the two-stage diffusion-controlled release from a poly(-lactic acid) matrix. J Control Release. 1999;61:295–304.
Sandor M, Enscore D, Weston P, Mathiowitz E. Effect of protein molecular weight on release from micron-sized PLGA microspheres. J Control Release. 2001;76:297–311.
Dunne M, Corrigan OI, Ramtoola Z. Influence of particle size and dissolution conditions on the degradation properties of polylactide-coglycolide particles. Biomaterials. 2000;21:1659–68.
Bittner B, Witt C, Mader K, Kissel T. Degradation and protein release properties of microspheres prepared from biodegradable poly(lactide-coglycolide) and ABA triblock copolymers: influence of buffer media on polymer erosion and bovine serum albumin release. J Control Release. 1999;60:297–309.
Siepmann J, Faisant N, Akiki J, Richard J, Benoit JP. Effect of the size of biodegradable microparticles on drug release: experiment and theory. J Control Release. 2004;96:123–34.
Liggins RT, Burt HM. Paclitaxel loaded poly(-lactic acid) (PLLA) microspheres: II. The effect of processing parameters on microsphere morphology and drug release kinetics. Int J Pharm. 2004;281:103–6.
Gumusderelioglu M, Deniz G. Sustained release of mitomycin-C from poly(DL-lactide) poly(DL-lactide-co-glycolide) films. J Biomater Sci. 2000;11:1039–50.
Ehtezazi T, Washington C. Controlled release of macromolecules from PLA microspheres: using porous structure topology. J Control Release. 2000;68:361–72.
Cui F, Cun D, Tao A, Yang M, Shi K, Zhao M, et al. Preparation and characterization of melittin-loaded poly(DL-lactic acid) or poly(DL-lactic-co-glycolic acid) microspheres made by the double emulsion method. J Control Release. 2005;107:310–9.
Alexis F. Factors affecting the degradation and drug-release mechanism of poly(lactic acid) and poly(lactic acid)-co-(glycolic acid). Polym Int. 2005;54:36–46.
Makino K, Ohshima H, Kondo T. Mechanism of hydrolytic degradation of poly(lactide) microcapsules: effects of pH, ionic strength and buffer concentration. J Microencapsul. 1986;3:203–12.
Aso Y, Yoshioka S, Li Wan Po A, Terao T. Effect of temperature on mechanisms of drug release and matrix degradation of poly(-lactide) microspheres. J Control Release. 1994;31:33–9.
Agrawal CM, Huang D, Schmitz JP, Athanasiou KA. Elevated temperature degradation of a 50:50 copolymer of PLA–PGA. Tissue Eng. 1997;3:345–52.
Loo SCJ, Ooi CP, Boey YCF. Radiation effects on poly(lactide-coglycolide) (PLGA) and poly(lactide) (PLLA). Polym Degrad Stab. 2004;83:259–65.
Burgess DJ, Hickey AJ. Microspheres: design and manufacturing. In: Burgess D, editor. Injectable dispersed systems: formulation, processing and performance. Boca Raton: Taylor and Francis; 2005. p. 305–53.
Hakkarainen M, Albertsson AC, Karlsson S. Weight losses and molecular weight changes correlated with the evolution of hydroxyacids in simulated in-vivo degradation of homo- and copolymers of PLA and PGA. Polym Degrad Stab. 1996;52:283–91.
Vavia PR, Puthli SP. Poly(lactide-co-glycolide) microspheres of levonorgestrel for parenteral contraception. J Pharm Pharmacol. 1998;50:144.
International Conference on Harmonization (ICH) Q1A(R2) Stability of new drug substances and products, 2003, CPMP/ICH/2736/99.
De A, Robinson D. Particle size and temperature effect on the physical stability of PLGA nanospheres and microspheres containing bodipy. AAPS PharmSciTech. 2004;5(4):53.
Puthli SP, Vavia PR. Stability indicating HPTLC determination of piroxicam. J Pharm Biomed Anal. 2000;22:73–677.
Burgess DJ, Crommelin DJA, Hussain AJ, Chen ML. Assuring quality and performance of sustained and controlled release parenterals. Eur J Pharm Sci. 2004;21:679–90.
Zolnik BS, Leary PE, Burgess DJ. Elevated temperature accelerated release testing of PLGA microspheres. J Control Release. 2006;112:293–300.
Higuchi T. Mechanism of sustained action medication: theoretical analysis of rate of release of solid drugs dispersed in solid matrices. J Pharm Sci. 1963;52:1145–9.
Shah MV, De Gennaro MD, Suryakasuma H. An evaluation of albumin microcapsules prepared using a multiple emulsion technique. J Microencapsul. 1987;4:223–38.
Doshi CC, Bhalla HL. In vitro release studies of levonorgestrel loaded biodegradable microspheres. Ind J Pharm Sci. 1999;61:39–43.
Ranga Rao KV, Padmalatha DK, Buri PK. Cellulose matrices for zero-order release of soluble drugs. Drug Dev Ind Pharm. 1988;14:2299–320.
Guidance for Industry, Dissolution Testing of Immediate Release Solid Oral Dosage Forms, U.S. Department of Health and Human Services, Food and Drug Administration Center for Drug Evaluation and Research (CDER). 1997. http://www.fda.gov/cder/Guidance/1713bp1.pdf
Ambrogi V, Perioli L, Marmottini F, Giovagnoli S, Esposito M, Rossi C. Improvement of dissolution rate of piroxicam by inclusion into MCM-41 mesoporous silicate. Eur J Pharm Sci. 2007;32:216–22.
Akers MJ, Fites AL, Robinson RL. Formulation, design and development of parenteral suspensions. J Parenter Sci Technol. 1987;41:88–96.
Freiberg S, Zhu XX. Polymer microspheres for controlled drug release. Int J Pharm. 2004;282:1–18.
Sinha VR, Trehan A. Biodegradable microspheres for protein delivery. J Control Release. 2003;90:261–80.
Zhu G, Mallery SR, Schwendeman SP. Stabilization of proteins encapsulated in injectable poly(lactide-co-glycolide). Nature Biotech. 2000;18:52–7.
Johansen P, Men Y, Audran R, Corradin G, Merkle HP, Gander B. Improving stability and release kinetics of microencapsulated tetanus toxoid by co-encapsulation of additives. Pharm Res. 1998;15:1103–10.
Csaba N, González L, Sánchez A, Alonso MJ. Design and characterization of new nanoparticulate polymer blends for drug delivery. J Biomater Sci Polym. 2004;15:1137–51.
Tobio M, Schwendeman SP, Guo Y, McIver J, Langer R, Alonso MJ. Improved immunogenicity of a core-coated tetanus toxoid delivery system. Vaccine. 2000;18:618–22.
Nakayama A, Kawasaki N, Yamamoto N, Maeda Y, Aiba S. Synthesis of biodegradable polyesters and effect of chemical structure on biodegradation. J Chem Soc Japan. 2001;1:1–9.
Saha SK, Tsuji H. Hydrolytic degradation of amorphous films of L-lactide copolymers with glycolide and D-lactide. Macromol Mater Eng. 2006;291:357–68.
Tsuji H, Tezuka Y, Yamada K. Alkaline and enzymatic degradation of L-lactidecopolymers. II. Crystallized films of poly(L-lactide-co-D-lactide) and poly(Llactide) with similar crystallinities. J Polym Sci Part B Polym Phys. 2005;43:1064–75.
Tsuji H, Ikeda Y. Properties and morphology of poly(L-lactide). II. Hydrolysis in alkaline solution. J Polym Sci Part A Polym Chem. 1998;36:59–66.
Lam KH, Nieuwenhuis P, Molenaar I. Biodegradation of porous versus nonporous poly(L-lactic acid) films. J Mater Sci Mater Med. 1994;5:181–91.
Loo SCJ, Ooi CP, Wee SHE, Boey YCF. Effect of isothermal annealing on the hydrolytic degradation rate of poly(lactide-co-glycolide) (PLGA). Biomaterials. 2005;26:2827–33.
Frank A, Rath SK, Venkatraman SS. Controlled release from bioerodible polymers: effect of drug type and polymer composition. J Control Release. 2005;102:333–44.
Li S, Girod-Holland S, Vert M. Hydrolytic degradation of poly(dl lactic acid) in the presence of caffeine base. J Control Release. 1996;40:41–53.
Acknowledgments
The authors would like to thank Purac Biochem for gifting poly(lactide-co-glycolide) and IPCA laboratories for piroxicam. The authors acknowledge the valuable help of Dr. Dixit in the preparation of this manuscript.
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Puthli, S., Vavia, P.R. Stability Studies of Microparticulate System with Piroxicam as Model Drug. AAPS PharmSciTech 10, 872–880 (2009). https://doi.org/10.1208/s12249-009-9280-8
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DOI: https://doi.org/10.1208/s12249-009-9280-8