Abstract
The purpose of this research was to develop the hydrodynamically balanced delivery system of Clarithromycin (CLA) which, after oral administration should have the ability to prolong gastric residence time with the desired in vitro release profile for the localized action in the stomach, in the treatment of Helicobacter pylori (H.pylori) mediated peptic ulcer. By applying wet granulation technique floating tablets of Clarithromycin were prepared. The proportion of sodium bicarbonate was varied to get the least possible lag time, also the polymer part varied to get the desired release. In vivo radiographic studies were performed with Barium sulphate loaded formulation to justify the increased gastric residence time of the dosage form in the stomach, based on the floating principle. The formulation developed using 66.2% Clarithromycin, 12% HPMC K4M polymer, 8% sodium bicarbonate gave floating lag time less than 3 min with a floating time of 12 h, and an in vitro release profile very near to the desired release. X-ray studies showed the enhanced gastric residence time of the tablet to 220 ± 30 min. The mechanism of release of Clarithromycin from the floating tablets is anomalous diffusion transport and follows zero order kinetics. In vivo radiographic studies suggest that the tablet has increased gastric residence time for the effective localized action of the antibiotic (Clarithromycin) in the treatment of H.pylori mediated peptic ulcer.
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References
R. Suman, R. B. Uma Maheshwari, and N. K. Jain. Clarithromycin based oral sustained release nanoparticulate drug delivery system. Indian J. Pharm. Sci. 68:479–484 (2006).
F. Fraschini, F. Scaglione, and G. Dermartini. Clarithromycin clinical pharmacokinetics. Clin. Pharmacokinet. 25:189–204 (1993).
P. L. Bardonnet, V. Faivre, W. J. Pugh, J. C. Piffaretti, and F. Falson. Review gastroretentive dosage forms: overview and special case of helicobacter pylori. J. Control. Release 111:1–18 (2006).
S. Arora, J. Ali, A. Ahuja, R. K. Khar, and S. Baboota. Floating drug delivery systems: review. AAPS PharmSciTech 6(3):E372–E390 (2005).
B. S. Kuchekar, A. A. Singavi, S. G. Late, and D. B. Shinde. Spectrophotometric estimation of roxithromycin and clarithromycin in pharmaceutical dosage forms. Indian Drugs 40(1):44–45 (2003).
M. Rosa, H. Zia, and T. Rhodes. Design and testing in vitro of a bioadhesive and floating drug delivery system for oral application. Int. J. Pharm. 105:65–70 (1994).
B. S. Kuchekar, A. A. Singavi, S. G. Late, and D. B. Shinde. Spectrophotometric estimation of roxithromycin and clarithromycin in pharmaceutical dosage forms. Indian Drugs 40(1):44–45 (2003).
P. L. Ritger, and N. A. Peppas. A simple equation for description of solute release. J. Control. Release 5:23–36 (1987).
P. Sriamornsak, N. Thirawong, and K. Korkerd. Swelling erosion and release behavior of alginate based matrix tablets. Eur. J. Pharm. Biopharm. 66(3):435–450 (2007).
C. S. Brazel, and N. A. Peppas. Modeling of drug release from swellable polymers. Eur. J. Pharm. Biopharm. 49:47–58 (2000).
Acknowledgements
The authors are expressing their sincere thanks to Cadila Pharmaceuticals, Ahmedabad Ind, for providing drug sample, Danmed Pharmaceuticals, Hyd, Ind, for providing gift samples of excipients. The authors also acknowledge St. Peter’s Institute of Pharmaceutical Sciences for providing facilities to carryout the research work and All Indian Council for Technical Education for providing financial assistance.
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Nama, M., Gonugunta, C.S.R. & Reddy Veerareddy, P. Formulation and Evaluation of Gastroretentive Dosage Forms of Clarithromycin. AAPS PharmSciTech 9, 231–237 (2008). https://doi.org/10.1208/s12249-008-9038-8
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DOI: https://doi.org/10.1208/s12249-008-9038-8