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Ultrasound Transmission Technique as a Potential Tool for Physical Evaluation of Monolithic Matrix Tablets

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Abstract

The aim of this study was to investigate the effects of tablet porosity and particle size fraction of compacted Starch acetate powders, with and without model drug caffeine, on acoustic properties of tablets. The ultrasound velocity was determined from the transmission measurements. Tablets of starch acetate (SA DS 2.7) powder with two particle size fractions of 0–53 and 0–710 μm were compressed with a compaction simulator. Porosities of tablets varied in the range from 12% to 43% for both particle size fractions. Strong associations were found between the ultrasound velocity and physical properties of the tablets such as porosity and particle size fraction. Interestingly, ultrasound velocity was practically insensitive to inclusion of the model drug caffeine with the concentrations used. Based on this study ultrasound transmission method is a potential non-destructive tool for studying structural changes of tablets and other solid dosage forms.

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Acknowledgements

The financial support from TEKES (Finnish Funding Agency for Technology and Innovation) COMBIO Program and VARMA project is gratefully acknowledged. This study was also financially and technically supported by the Finnish companies Orion Pharma Oyj, Polymer Corex Ltd. and Visipoint Oy. The authors are grateful to M.Sc. Laura Tomppo for her collaboration.

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Authors and Affiliations

  1. Department of Physics, BioMater Centre, University of Kuopio, P.O. Box 1627, 70211, Kuopio, Finland

    M. A. Hakulinen, J. Leskinen, K. Niinimäki, K. Pirskanen & R. Lappalainen

  2. Department of Pharmaceutics, University of Kuopio, P.O. Box 1627, 70211, Kuopio, Finland

    J. Pajander, J. Ketolainen & B. van Veen

  3. Department of Pharmaceutical Chemistry, University of Kuopio, P.O. Box 1627, 70211, Kuopio, Finland

    A. Poso

  4. Orion Pharma R&D, Orion Corporation, P.O. Box 65, 02101, Espoo, Finland

    B. van Veen

Authors
  1. M. A. Hakulinen
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  2. J. Pajander
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  3. J. Leskinen
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  4. J. Ketolainen
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  5. B. van Veen
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  6. K. Niinimäki
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  7. K. Pirskanen
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  8. A. Poso
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  9. R. Lappalainen
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Correspondence to M. A. Hakulinen.

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Hakulinen, M.A., Pajander, J., Leskinen, J. et al. Ultrasound Transmission Technique as a Potential Tool for Physical Evaluation of Monolithic Matrix Tablets. AAPS PharmSciTech 9, 267–273 (2008). https://doi.org/10.1208/s12249-007-9010-z

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  • DOI: https://doi.org/10.1208/s12249-007-9010-z

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