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The AAPS Journal

, Volume 19, Issue 4, pp 1029–1044 | Cite as

Controlled Ion Release from Novel Polyester/Ceramic Composites Enhances Osteoinductivity

  • Soheila Ali Akbari Ghavimi
  • Rama Rao TataEmail author
  • Andrew J. Greenwald
  • Brittany N. Allen
  • David A. Grant
  • Sheila A. Grant
  • Mark W. Lee
  • Bret D. UleryEmail author
Research Article Theme: Recent Advances in Musculoskeletal Tissue Engineering
Part of the following topical collections:
  1. Theme: Recent Advances in Musculoskeletal Tissue Engineering

Abstract

Due to the growing number of patients suffering from musculoskeletal defects and the limited supply of and sub-optimal outcomes associated with biological graft materials, novel biomaterials must be created that can function as graft substitutes. For bone regeneration, composite materials that mimic the organic and inorganic phases of natural bone can provide cues which expedite and enhance endogenous repair. Specifically, recent research has shown that calcium and phosphate ions are inherently osteoinductive, so controllably delivering their release holds significant promise for this field. In this study, unique aliphatic polyesters were synthesized and complexed with a rapidly decomposing ceramic (monobasic calcium phosphate, MCP) yielding novel polymer/ceramic composite biomaterials. It was discovered that the fast dissolution and rapid burst release of ions from MCP could be modulated depending on polymer length and chemistry. Also, controlled ion release was found to moderate solution pH associated with polyester degradation. When composite biomaterials were incubated with mesenchymal stems cells (MSCs) they were found to better facilitate osteogenic differentiation than the individual components as evidenced by increased alkaline phosphate expression and more rapid mineralization. These results indicate that controlling calcium and phosphate ion release via a polyester matrix is a promising approach for bone regenerative engineering.

KEY WORDS

calcium/phosphate ions mesenchymal stem cells monobasic calcium phosphate osteoinduction polyesters 

Notes

Acknowledgements

The authors gratefully acknowledge support from start-up funds provided by the University of Missouri. We also thank the Jost Chemical Company for providing the monobasic calcium phosphate and specifically Jerry Jost, Doug Jost, and Joe Hardimon for valuable discussion regarding this research. AJG and BNA thank the Discovery Fellows Program at the University of Missouri for their support.

Supplementary material

12248_2017_72_MOESM1_ESM.pdf (2.5 mb)
ESM 1 (PDF 2524 kb)

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Copyright information

© American Association of Pharmaceutical Scientists 2017

Authors and Affiliations

  • Soheila Ali Akbari Ghavimi
    • 1
  • Rama Rao Tata
    • 1
    Email author
  • Andrew J. Greenwald
    • 1
  • Brittany N. Allen
    • 2
  • David A. Grant
    • 2
  • Sheila A. Grant
    • 2
  • Mark W. Lee
    • 3
  • Bret D. Ulery
    • 1
    • 2
    Email author
  1. 1.Department of Chemical EngineeringUniversity of MissouriColumbiaUSA
  2. 2.Department of BioengineeringUniversity of MissouriColumbiaUSA
  3. 3.Department of ChemistryUniversity of MissouriColumbiaUSA

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