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Evaluation of polymerized rosin for the formulation and development of transdermal drug delivery system: A technical note

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Conclusions

Results from the present study conclude that PR in combination with PVP and with incorporation of dibutyl phthalate (30% wt/wt) produces smooth flexible films with improved tensile strength and percentage elongation. The release rate of drug from films and permeation across skin increases with increase in drug and PVP loading but is independent of film thickness. Patches containing PR:PVP (7:3) show promise for pharmacokinetic and pharmacodynamic performance evaluation in a suitable animal model. In view of the overall results reported in the present study, it may be proposed that PR can be used in the design of a matrix type transdermal drug delivery system to prolong the drug release.

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References

  1. Pathak YV, Shinghatgiri M, Dorle AK. In vivo performance of pentastergum coated aspirin microcapsules.J Microencapsul. 1987;4:107–110.

    Article  CAS  Google Scholar 

  2. Sheorey DS, Dorle AK. Release kinetics & drugs from rosin-glycerol ester microcapsules prepared by solvent evaporation technique.J Microencapsul. 1991;8:243–246.

    Article  CAS  Google Scholar 

  3. Pathak YV, Dorle AK. Rosin and rosin derivatives as hydrophobic matrix materials for controlled release of drugs.Drug Des Deliv. 1990;6:223–227.

    CAS  Google Scholar 

  4. Ramani CC, Puranik PK, Dorle AK. Study of rosin-maleoabietic acid as a matrix forming materials.Int J Pharm Adv. 1996;1:344–352.

    CAS  Google Scholar 

  5. Pathak YV, Nikore RL, Dorle AK. Study of rosin and esters as coating materials.Int J Pharm. 1985;24:351–354.

    Article  CAS  Google Scholar 

  6. Ramani CC, Puranik PK, Dorle AK. Study of diabietic acid as matrix forming material.Int J Pharm. 1996;137:11–19.

    Article  CAS  Google Scholar 

  7. Sahu NH, Mandaogade PM, Deshmukh AM, Meghre VS, Dorle AK. Biodegradation studies of rosin-glycerol ester derivative.J Bioact Comp Polym. 1999;14:344–360.

    CAS  Google Scholar 

  8. Fulzele SV, Satturwar PM, Dorle AK. Studies on biodegradation and in vivo biocompatibility of novel biomaterials.Eur J Pharm Sci. 2003;20:53–61.

    Article  CAS  Google Scholar 

  9. Chien YW. Comparative controlled skin permeation of nitroglycerin from marketed transdermal delivery systems.J Pharm Sci. 1983; 72:968–970.

    Article  CAS  Google Scholar 

  10. Loftsson T, Gildersleeve N, Border N. The effect of vehicle additives on the transdermal delivery of nitroglycerin.Pharm Res. 1987; 4:436–444.

    Article  CAS  Google Scholar 

  11. Corbo M, Liu JC, Chien YW. Bioavailability of propranolol following oral & transdermal administration in rabbits.J Pharm Sci. 1990;79:584–587.

    Article  CAS  Google Scholar 

  12. Aqil M, Sultana Y, Ali A. Matrix type transdermal drug delivery systems of metoprolol tartrate: in vitro characterization.Acta Pharm. 2003;53:119–125.

    CAS  Google Scholar 

  13. Williams AC, Barry BW. Penetration enhancers.Adv Drug Deliv Rev. 2004;56:603–618.

    Article  CAS  Google Scholar 

  14. Bohme K. Buprenorphine in a transdermal therapeutic system—a new option.Clin Rheumatol. 2002;21:S13-S16.

    Article  Google Scholar 

  15. Dhanorkar VT, Gawande RS, Gogte BB, Dorle AK. Development and characterization of rosin-based polymer and its application as a cream base.J Cosmet Sci. 2002;53:199–208.

    CAS  Google Scholar 

  16. Fulzele SV, Satturwar PM, Dorle AK. Polymerized rosin: novel filmforming polymer for drug delivery.Int J Pharm. 2002;249:175–184.

    Article  CAS  Google Scholar 

  17. Gigante B, Jones R, Lobo AM, et al. The structure of an abietic acid dimer.J Chem Soc Chem Commun. 1986;22:1038–1039.

    Article  Google Scholar 

  18. Parkin BA, Walter H, inventors. Polymerized rosin product and method of preparation of the same. US patent 3 891 612. June 12, 1975.

  19. Gupta R, Mukherjee B. Development and in vitro evaluation of diltiazem hydrochloride transdermal patches on povidone-ethylcellulose matrices.Drug Dev Ind Pharm. 2003;29:1–7.

    Article  CAS  Google Scholar 

  20. Jain SK, Chaurasia MK, Sabitha M, et al. Development and characterization of transdermal drug delivery systems for diltiazem hydrochloride.Drug Deliv. 2003;10:169–177.

    Article  CAS  Google Scholar 

  21. Lee PJ, Langer R, Shastri VP. Novel microemulsion enhancer formulation for simultaneous transdermal delivery of hydrophilic and hydrophobic drugs.Pharm Res. 2003;20:264–269.

    Article  CAS  Google Scholar 

  22. Baichwal RW.Advances in drug delivery systems. Bombay, India: MSR foundation; 1983:136–147.

    Google Scholar 

  23. British Pharmacopoeia Commission.British Pharmacopoeia. Addendum 1996. London, UK: British Pharmacopoeia Commission; 1996:1761.

    Google Scholar 

  24. United States Pharmacopeial Convention.United States Pharmacopeia. 23rd ed. Rockville, MD: United States Pharmacopeial Convention; 1993:1796.

    Google Scholar 

  25. Chien YW, Valia KH. Development of a dynamic skin permeation system for long term studies.Drug Dev Ind Pharm. 1984;10:575–599.

    Article  CAS  Google Scholar 

  26. Sarpotdar PP, Gaskill JL, Giannini RP. Effect of polyethylene glycol 400 on the penetration of drugs through human cadaver skin in vitro.J Pharm Sci. 1986;75:26–28.

    Article  CAS  Google Scholar 

  27. Draize JH, Woodward GS, Calvery HO. Method for the study of irritation and toxicity of substances applied topically to the skin and mucus membrane.J Pharmacol Expt Therap. 1994;82:377–390.

    Google Scholar 

  28. Arora P, Mukherjee B. Design, development, physicochemical, and in vitro and in vivo evaluation of transdermal patches containing diclofenac diethylammonium salt.J Pharm Sci. 2002;91:2076–2089.

    Article  CAS  Google Scholar 

  29. Sood A, Panchagnula R. Role of dissolution studies in controlled release drug delivery system.STP Pharma Sci. 1999;9:157–168.

    CAS  Google Scholar 

  30. Bodmeier R, Paeratakul O. Theophylline tablets coated with aqueous latexes containing dispersed pore formers.J Pharm Sci. 1990; 79:925–928.

    Article  CAS  Google Scholar 

  31. Megrab NA, Williams AC, Barray BW. Oestradiol permeation through human skin and silastic membrane: effects of propylene glycol and supersaturation.J Control Release. 1995;36:277–294.

    Article  CAS  Google Scholar 

  32. Rao PR, Ramakrishna S, Diwan PV. Drug release kinetics from polymeric films containing propranolol hydrochloride for transdermal use.Pharm Dev Technol. 2000;5:465–472.

    Article  CAS  Google Scholar 

  33. Katayose S, Kataoka K. Water soluble polyion complex associates of DNA and poly(ethylene glycol)- poly(l-lysine) block copolymers.Bioconjug Chem. 1997;8:702–707.

    Article  CAS  Google Scholar 

  34. Chien YW. Development of transdermal drug delivery system.Drug Dev Ind Pharm. 1987;13:589–651.

    Article  CAS  Google Scholar 

  35. Johnson ME, Blankschtein D, Linger R. Evaluation of solute permeation through the stratum corneum: lateral bilayer diffusion as the primary transport mechanism.J Pharm Sci. 1997;86:1162–1172.

    Article  CAS  Google Scholar 

  36. Burger GT, Cheryl ML. Animal care and facilities. In: Hayes AW, ed.Principals and Methods of Toxicology. 2nd ed. New York, NY: Raven Press Ltd; 1989:521–552.

    Google Scholar 

  37. Rao PR, Diwan PV. Formulation and in vitro evaluation of polymeric films of diltiazem hydrochloride and indomethacin for transdermal administration.Drug Dev Ind Pharm. 1998;24:327–336.

    Article  CAS  Google Scholar 

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Author notes

  1. Prashant M. Satturwar

    Present address: Faculty of Pharmacy, University of Montreal, H3T 1J4, Montreal, Quebec, Canada

  2. Suniket V. Fulzele

    Present address: College of Pharmacy and Pharmaceutical Sciences, Florida A&M University, 32307, Tallahassee, FL

Authors and Affiliations

  1. Department of Pharmaceutical Sciences, Nagpur University Campus, Amravati Road, 440033, Nagpur, India

    Prashant M. Satturwar, Suniket V. Fulzele & Avinash K. Dorle

Authors
  1. Prashant M. Satturwar
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  2. Suniket V. Fulzele
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  3. Avinash K. Dorle
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Correspondence to Prashant M. Satturwar.

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Published: December 27, 2005

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Satturwar, P.M., Fulzele, S.V. & Dorle, A.K. Evaluation of polymerized rosin for the formulation and development of transdermal drug delivery system: A technical note. AAPS PharmSciTech 6, 81 (2005). https://doi.org/10.1208/pt060481

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  • DOI: https://doi.org/10.1208/pt060481

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