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Investigation of processing parameters of spray freezing into liquid to prepare polyethylene glycol polymeric particles for drug delivery

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Abstract

The objective of this study was to investigate the influence of processing parameters on the morphology, porosity, and crystallinity of polymeric polyethylene glycol (PEG) microparticles by spray freezing into liquid (SFL), a new particle engineering technology. Processing parameters investigated were the viscosity and flow rate of the polymer solution, nozzle diameter, spray time, pressure, temperature, and flow rate of the cryogenic liquid. By varying the processing parameters and feed composition, atomization and heat transfer mechanisms were modified resulting in particles of different size distribution, shape, morphology, density, porosity, and crystallinity. Median particle diameter (M50) varied from 25 μm to 600 μm. Particle shape was spherical or elongated with highly irregular surfaces. Granule density was between 0.5 and 1.5 g/mL. In addition to producing particles of pure polymer, drug particles were encapsulted in polymeric microparticles. The encapsulation efficiency of albuterol sulfate was 96.0% with a drug loading of 2.4%, indicating that SFL is useful for producing polymeric microparticles for drug delivery applications. It was determined that the physicochemical characteristics of model polymeric microparticles composed of PEG could be modified for use as a drug delivery carrier.

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Authors and Affiliations

  1. Theravance Inc, South San Francisco, CA

    Melisa K. Barron

  2. Dow Chemical Company, Midland, MI

    Timothy J. Young

  3. Department of Chemical Engineering, University of Texas at Austin, Austin, TX

    Keith P. Johnston

  4. College of Pharmacy, University of Texas at Austin, A1920, 78712, Austin, TX

    Robert O. Williams

Authors
  1. Melisa K. Barron
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  2. Timothy J. Young
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  3. Keith P. Johnston
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  4. Robert O. Williams
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Correspondence to Robert O. Williams.

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Barron, M.K., Young, T.J., Johnston, K.P. et al. Investigation of processing parameters of spray freezing into liquid to prepare polyethylene glycol polymeric particles for drug delivery. AAPS PharmSciTech 4, 12 (2003). https://doi.org/10.1208/pt040212

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  • DOI: https://doi.org/10.1208/pt040212

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