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Powder and mechanical properties of microcrystalline cellulose with different degrees of polymerization

AAPS PharmSciTech volume 3, pages 45–54 (2002)Cite this article

Abstract

This study investigated the influence of the degree of polymerization (DP) of cellulose materials (microcrystalline cellulose [MCC]) on some powder properties and the compression behavior of these materials. The DP was determined by measurements of viscosity (H). The weight average of molecular weight and the weight average of the different DPs were investigated after MCC was modified to cellulose tricarbanilate by light scattering measurements. The DP showed a remarkable influence on the physicochemical properties of the cellulose materials and, consequently, on the behavior of these materials during compression. MCC types with a high DP value showed greater water absorption than the types with a low DP value. No relevant relationship between the crystallinity index and the DP could be observed. DP 190 showed lower compactibility and compressibility parameters than DP 244 and 299. No significant differences could be observed between DP 244 and 299 when the same particle size fraction was compressed. Furthermore, the compressibility was increased by increasing the DP.

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Affiliations

  1. Solvay Pharmaceuticals, Hans-Böckler-Alle 20, 30173, Hannover, Germany

    G. Shlieout

  2. Institute for Pharmaceutics and Biopharmaceutics, Martin Luther University, Halle-Wittenberg, D-06099, Halle, Germany

    K. Arnold

  3. Institute of Technical Chemistry and Macromolecular Chemistry, Martin Luther University, Halle-Wittenberg, D-06099, Halle, Germany

    G. Müller

Authors
  1. G. Shlieout
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  2. K. Arnold
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  3. G. Müller
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Correspondence to G. Shlieout.

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Shlieout, G., Arnold, K. & Müller, G. Powder and mechanical properties of microcrystalline cellulose with different degrees of polymerization. AAPS PharmSciTech 3, 45–54 (2002). https://doi.org/10.1208/pt030211

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  • DOI: https://doi.org/10.1208/pt030211

Key Words

  • microcrystalline cellulose
  • degree of polymerization
  • light scattering
  • cellulose tricarbanilate
  • compression
  • tablet