AAPS PharmSciTech

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Drug–Lipid Conjugates for Enhanced Oral Drug Delivery

  • Tushar Date
  • Kaushani Paul
  • Navneet Singh
  • Sanyog JainEmail author
Review Article Theme: Lipid-Based Drug Delivery Strategies for Oral Drug Delivery
Part of the following topical collections:
  1. Theme: Lipid-Based Drug Delivery Strategies for Oral Drug Delivery


Oral drug delivery route is one of the most convenient and extensively utilised routes for drug administration. But there exists class of drugs which exhibit poor bioavailability on oral drug administration. Designing of drug–lipid conjugates (DLCs) is one of the rationale strategy utilised in overcoming this challenge. This review extensively covers the various dimensions of drug modification using lipids to attain improved oral drug delivery. DLCs help in improving oral delivery by providing benefits like improved permeability, stability in gastric environment, higher drug loading in carriers, formation of self-assembled nanostructures, etc. The clinical effectiveness of DLCs is highlighted from available marketed drug products along with many DLCs in phase of clinical trials. Conclusively, this drug modification strategy can potentially help in augmenting oral drug delivery in future.


lipid–drug conjugate permeability oral drug delivery bioavailability 



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© American Association of Pharmaceutical Scientists 2019

Authors and Affiliations

  • Tushar Date
    • 1
  • Kaushani Paul
    • 1
  • Navneet Singh
    • 1
  • Sanyog Jain
    • 1
    Email author
  1. 1.Centre for Pharmaceutical Nanotechnology, Department of PharmaceuticsNational Institute of Pharmaceutical Education and Research (NIPER)NagarIndia

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