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AAPS PharmSciTech

, 20:68 | Cite as

Structure-Based Gastro-Retentive and Controlled-Release Drug Delivery with Novel 3D Printing

  • Haoyang Wen
  • Bosai He
  • Haoyu Wang
  • Fen Chen
  • Pingfei Li
  • Mengsuo Cui
  • Qijun Li
  • Weisan PanEmail author
  • Xinggang YangEmail author
Research Article

Abstract

In the present contribution, the aim is to explore and establish a way in which 3D printing and gastro-retentive drug delivery systems (GRDDSs) are combined (focusing on inner structure innovation) to achieve extended and stable gastro-retention and controlled-release of drug. Three digital models diverse in construction were designed and substantialized by a pressure-assisted microsyringe (PAM) 3D printer. Preparations were characterized by means of DSC, XRD, FTIR, and SEM. In vitro buoyancy study and in vivo gamma scintigraphy method were conducted to validate gastro-retention property of these innovative preparations in vitro/in vivo respectively. Release kinetic model was established and release mechanism was discussed. Tablets manufactured under certain range of parameters (intersecting angle, full filling gap) were tight and accurate in shape. Tablets printed with specific parameters (full filling gap, 50%; nozzle extrusion speed, 0.006 mm/s; layer height, 0.4 mm; compensation value, 0.25; quantity of layers, 15; outline printing value, 2) exhibited satisfactory in vitro (10–12 h)/in vivo (8–10 h) retention ability and possessed stable 10–12 h controlled-release quality. In general, 3D printing has tremendous advantage over conventional fabrication technique in intricate drug delivery systems and will be widely employed in pharmacy.

KEY WORDS

3D printing ginkgolide controlled-release gastro-retention gamma scintigraphy 

Notes

Acknowledgments

We wish to acknowledge that this work was supported by National Science and Technology Major Project which belongs to “The research on the key technology of new drug delivery system and industrialization of new projects” (No. 2014ZX09507001004), and the Open Fund of Key Laboratory of Ministry of Education for TCM Viscera-State Theory and Applications, Liaoning University of Traditional Chinese Medicine, which belongs to “Research of gastro-retentive and control-released preparation of ginkgolide” (No.zyzx1608).

Compliance with Ethical Standards

Ethical Approval

All procedures performed in this research involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

Conflict of Interest

The authors declare that they have no conflicts of interest.

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Copyright information

© American Association of Pharmaceutical Scientists 2019

Authors and Affiliations

  • Haoyang Wen
    • 1
  • Bosai He
    • 2
  • Haoyu Wang
    • 1
  • Fen Chen
    • 3
  • Pingfei Li
    • 1
  • Mengsuo Cui
    • 1
  • Qijun Li
    • 1
  • Weisan Pan
    • 1
    Email author
  • Xinggang Yang
    • 1
    • 3
    Email author
  1. 1.Department of Pharmaceutics, School of PharmacyShenyang Pharmaceutical UniversityShenyangChina
  2. 2.School of Functional Food and WineShenyang Pharmaceutical UniversityShenyangChina
  3. 3.Key Laboratory of Ministry of Education for TCM Viscera-State Theory and ApplicationsLiaoning University of Traditional Chinese MedicineShenyangChina

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