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AAPS PharmSciTech

, Volume 19, Issue 7, pp 3187–3198 | Cite as

Preclinical Explorative Assessment of Celecoxib-Based Biocompatible Lipidic Nanocarriers for the Management of CFA-Induced Rheumatoid Arthritis in Wistar Rats

  • Pradip Nirbhavane
  • Gajanand Sharma
  • Bhupinder Singh
  • Gopal K Khuller
  • Vijay G Goni
  • A. B. Patil
  • Om Prakash Katare
Research Article

Abstract

Celecoxib (CXB), a COX-2 inhibitor, is primarily indicated for long-term treatment of rheumatoid arthritis (RA). The effective therapeutic efficacy of CXB on RA via oral administration shows adverse systemic complications, and therefore, local application of CXB has been recommended. The aim of the present study was to develop and characterize solid lipid nanoparticles (SLNs) with enhanced skin permeation potential of CXB. The particle size, polydispersity index (PDI), and percentage drug entrapment (PDE) of the developed SLNs (CXB-SLNs) were found to be 240 nm, < 0.3, and ~ 86% respectively. The developed SLNs exhibited sustained release up to 70% at the end of 48 h. Drug permeation was found to be 45% for SLN gel and 31% for conventional gel. The dermatokinetic studies also confirmed enhanced permeation of CXB in the epidermis and dermis and revealed superiority of the developed SLN gel vis-à-vis the conventional gel. Further, in the CFA-induced arthritis rat model, % arthritis index (AI) of the CXB-SLN gel formulation was found to be very less (18.54%) as compared to untreated (187.34%) and conventional gel-treated (91.61%) animals. In conclusion, the current study can provide a suitable alternative for the development of an effective topical formulation of CXB in lipid nanocarriers.

KEY WORDS

celecoxib lipid nanocarriers skin permeation rheumatoid arthritis 

Notes

Funding Information

The first author received an SRF fellowship from the Indian Council of Medical Research (ICMR), New Delhi (ref no. 45/31/2013-Nan/BMS).

Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no conflict of interest.

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Copyright information

© American Association of Pharmaceutical Scientists 2018

Authors and Affiliations

  • Pradip Nirbhavane
    • 1
  • Gajanand Sharma
    • 1
  • Bhupinder Singh
    • 1
    • 2
  • Gopal K Khuller
    • 3
  • Vijay G Goni
    • 4
  • A. B. Patil
    • 5
  • Om Prakash Katare
    • 1
  1. 1.University Institute of Pharmaceutical Sciences, UGC Centre of Advanced StudiesPanjab UniversityChandigarhIndia
  2. 2.UGC-Centre of Excellence in Applications of Nanomaterials, Nanoparticles & Nanocomposites (Biomedical Sciences)Panjab UniversityChandigarhIndia
  3. 3.Department of BiochemistryPostgraduate Institute of Medical Education and ResearchChandigarhIndia
  4. 4.Department of OrthopaedicsPostgraduate Institute of Medical Education and ResearchChandigarhIndia
  5. 5.Department of OrthopedicsGadag Institute of Medical Sciences (GIMS)GadagIndia

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