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AAPS PharmSciTech

, Volume 19, Issue 8, pp 3388–3402 | Cite as

Pharmaceutical Additive Manufacturing: a Novel Tool for Complex and Personalized Drug Delivery Systems

  • Jiaxiang Zhang
  • Anh Q. Vo
  • Xin Feng
  • Suresh Bandari
  • Michael A. Repka
Review Article Theme: Printing and Additive Manufacturing
  • 315 Downloads
Part of the following topical collections:
  1. Theme: Printing and Additive Manufacturing

Abstract

Inter-individual variability is always an issue when treating patients of different races, genders, ages, pharmacogenetics, and pharmacokinetic characteristics. However, the development of novel dosage forms is limited by the huge investments required for production line modifications and dosages diversity. Additive manufacturing (AM) or 3D printing can be a novel alternative solution for the development of controlled release dosages because it can produce personalized or unique dosage forms and more complex drug-release profiles. The primary objective of this manuscript is to review the 3D printing processes that have been used in the pharmaceutical area, including their general aspects, materials, and the operation of each AM technique. Advantages and shortcomings of the technologies are discussed with respect to practice and practical applications. Thus, this review will provide an overview and discussion on advanced pharmaceutical AM technologies, which can be used to produce unique controlled drug delivery systems and personalized dosages for the future of personalized medicine.

KEY WORDS

pharmaceutical additive manufacturing 3D printing drug delivery system personalized dosages patient-centered drug development 

Notes

Acknowledgements

The authors thank the Pii Center for Pharmaceutical Technology for contributions in this project.

Funding Information

This work was partially supported by Grant Number P20GM104932 from the National Institute of General Medical Sciences (NIGMS), a component of NIH.

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Copyright information

© American Association of Pharmaceutical Scientists 2018

Authors and Affiliations

  • Jiaxiang Zhang
    • 1
  • Anh Q. Vo
    • 1
  • Xin Feng
    • 1
  • Suresh Bandari
    • 1
  • Michael A. Repka
    • 1
    • 2
  1. 1.Department of Pharmaceutics and Drug Delivery, School of PharmacyUniversity of MississippiUniversityUSA
  2. 2.Pii Center for Pharmaceutical TechnologyThe University of MississippiUniversityUSA

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