Flutamide-Loaded Zein Nanocapsule Hydrogel, a Promising Dermal Delivery System for Pilosebaceous Unit Disorders
- 76 Downloads
Zein is a naturally occurring corn protein having similarity to skin keratin. Owing to its hydrophobicity and biodegradability, zein nanocarriers are promising drug delivery vehicles for hydrophobic dermatological drugs. In this study, zein-based nanocapsules (ZNCs) were exploited for the first time as dermal delivery carriers for flutamide (FLT), an antiandrogen used for the management of pilosebasceous unit disorders. FLT-loaded ZNC of appropriate particle size and negative surface charge were prepared by nanoprecipitation method. The dermal permeation and skin retention of FLT from ZNCs were studied in comparison to corresponding nanoemulsion (NE) and hydroalcoholic drug solution (HA). ZNCs showed a significantly lower permeation flux compared to NE and HA while increasing the skin retention of FLT. Confocal laser scanning microscopy (CLSM) demonstrated the follicular localization of the fluorescently labeled NCs. The incorporation of NCs in chitosan gel or Carbomer® 934 gel was studied. Carbomer® gel increased the skin retention of FLT compared to chitosan gel. Accordingly, Carbomer® hydrogel embedding FLT-loaded ZNCs is a promising inexpensive, biocompatible dermal delivery nanocarrier for localized therapy of PSU disorders suitable for application on oily skin.
KEY WORDSzein pilosebaceous unit confocal imaging follicular targeting flutamide
This work is supported by a research grant funded by center of special studies at bibliotheca Alexandrina (CSSP-BIBALEX).
Compliance with Ethical Standards
Conflict of Interest
The authors reported no conflict of interest.
- 9.Durán N, Teixeira Z, Marcato PD. Topical application of nanostructures: solid lipid, polymeric and metallic nanoparticles. Nanocosmetics and Nanomedicines: Springer. 2011. p. 69–99.Google Scholar
- 12.Sallam MA, Marin Bosca MT. Mechanistic analysis of human skin distribution and follicular targeting of adapalene-loaded biodegradable Nanospheres with an insight into hydrogel matrix influence, in vitro skin irritation, and in vivo tolerability. J Pharm Sci. 2017;106(10):3140–9.CrossRefPubMedGoogle Scholar
- 15.Poletto FS, Beck RC, Guterres SS, Pohlmann AR. Polymeric nanocapsules: concepts and applications. Nanocosmetics and nanomedicines: Springer; 2011. p. 49–68.Google Scholar
- 30.Elzoghby A, Freag M, Mamdouh H, Elkhodairy K. Zein-based nanocarriers as potential natural alternatives for drug and gene delivery: focus on cancer therapy. Curr Pharm Des. 2017.Google Scholar
- 46.Machida Y, Masuda H, Fujiyama N, Iwata M, Nagai T. Preparation and phase II clinical examination of topical dosage forms for the treatment of carcinoma colli containing bleomycin, carboquone, or 5-fluorouracil with Hydroxypropyl cellulose. Chem Pharm Bull (Tokyo). 1980;28(4):1125–30.CrossRefGoogle Scholar