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AAPS PharmSciTech

, Volume 19, Issue 5, pp 2288–2300 | Cite as

Application of Solvent Parameters for Predicting Organogel Formation

  • Beibei Hu
  • Wei Sun
  • Baixue Yang
  • Heran Li
  • Liuchenzi Zhou
  • Sanming Li
Research Article
  • 70 Downloads

Abstract

Solvents, accounting the majority of the organogel system, have a tremendous impact on the characteristics of gels. To date, there is a large variety of organogel systems; relatively few have been investigated in the field of structure-solvent correlation. Here, a series of solvent parameters were applied to explore the role of solvent effect on network forming and gel property, intending to build the connection between the precise solvent parameter and gel property. Among the solvent parameters, Kamlet–Taft Parameters and Hansen solubility parameters can distinguish specific types of intermolecular interactions, which could correlate solvent parameter with the gel property. From an analysis of the morphologies obtained from POM and SEM, the gelator structure has an impact on its self-assembly. For possible conformations, the gelators were investigated through XRD. The investigation of solvent-property relationship will provide a theoretical basis for controllable drug delivery implants.

KEY WORDS

solvent parameter Hansen solubility parameters gelation organogels 

Notes

Funding Information

This work was supported by National Natural Science Foundation of China under Grant No. 81273445.

Supplementary material

12249_2018_1074_MOESM1_ESM.docx (974 kb)
ESM 1 (DOCX 973 kb)

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Copyright information

© American Association of Pharmaceutical Scientists 2018

Authors and Affiliations

  • Beibei Hu
    • 1
  • Wei Sun
    • 1
  • Baixue Yang
    • 1
  • Heran Li
    • 1
  • Liuchenzi Zhou
    • 1
  • Sanming Li
    • 1
  1. 1.School of PharmacyShenyang Pharmaceutical UniversityBenxiPeople’s Republic of China

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