Investigation of Carrageenan Aerogel Microparticles as a Potential Drug Carrier
- 271 Downloads
Carrageenan is an anionic polysaccharide offering many advantages to be used in drug delivery applications. These include availability, thermo-stability, low toxicity, and encapsulating properties. Combination of these properties with aerogel properties like large surface area and porosity make them an ideal candidate for drug adsorption and delivery applications. Emulsion-gelation technique was used to prepare carrageenan gel microparticles with supercritical CO2 for drying and loading purposes. Ibuprofen has been selected as a model drug for drug loading inside. The prepared microparticles were characterized using particle size analysis, X-ray diffraction, differential scanning calorimetry, Fourier transform infrared spectroscopy, density measurements, surface area, and porosity measurements. Finally, dissolution was applied to the loaded preparations to test in vitro drug release. Ibuprofen was successfully loaded in the amorphous form inside the prepared microparticles with a significant enhancement in the drug release profile. In conclusion, prepared carrageenan aerogel microparticles showed an excellent potential for use as a drug carrier.
KEY WORDScarrageenan Aerogels ibuprofen microparticles amorphous
The authors would like to thank Deanship of Research at Jordan University of Science and Technology (JUST) for funding this project with fund number 9/2017. The authors would like to acknowledge Scientific Research Funds (SRF) at Ministry of Higher Education (Amman, Jordan) for funding the SFT unit (MPH/2/15/2013).
Compliance with Ethical Standards
Conflict of Interest
The authors declare that they have no conflicts of interest.
- 1.Dumitriu S. Polysaccharides: structural diversity and functional versatility, second edition, CRC press; 2004.Google Scholar
- 3.Rowe RC, Sheskey PJ, Owen SC. Handbook of pharmaceutical excipients. London: APhA/Pharmaceutical Press. 2009. Print.Google Scholar
- 4.Stortz CA, Cerezo AS. Novel findings in carrageenans, agaroids and “hybrid” red seaweed galactans. ChemInform. 2010;33(15)Google Scholar
- 7.Ozsoy Y, Bergişadi N. Preparation of mefenamic acid sustained release beads based on kappa-carrageenan. Boll Chim Farm. 1999;139(3):120–3.Google Scholar
- 13.Sathuvan M, Thangam R, Gajendiran M, Vivek R, Balasubramanian S, Nagaraj S, et al. κ-Carrageenan: an effective drug carrier to deliver curcumin in cancer cells and to induce apoptosis. Carbohydr Polym. 2017;160:184–93.Google Scholar
- 15.Tomoda K, Asahiyama M, Ohtsuki E, Nakajima T, Terada H, Kanebako M, et al. Preparation and properties of carrageenan microspheres containing allopurinol and local anesthetic agents for the treatment of oral mucositis. Colloids Surf B: Biointerfaces. 2009;71(1):27–35.Google Scholar
- 18.Nanaki SG, Kyzas GZ, Tzereme A, Papageorgiou M, Kostoglou M, Bikiaris DN, et al. Synthesis and characterization of modified carrageenan microparticles for the removal of pharmaceuticals from aqueous solutions. Colloids Surf B: Biointerfaces. 2015;127:256–65.Google Scholar
- 20.Yin W, Rubenstein DA. Biomedical applications of aerogels. In: Aegerter M., Leventis N., Koebel M. (eds) Aerogels Handbook. Advances in Sol-Gel Derived Materials and Technologies: Springer; 2011. p. 683–94. Google Scholar
- 22.Mayer ST, Kong FM, Pekala RW, Kaschmitter JL. Organic aerogel microspheres and fabrication method therefor. 1996. U.S. Patent 5,508,341.Google Scholar
- 26.Alnaief M, Obaidat R, Mashaqbeh H. Effect of processing parameters on preparation of carrageenan aerogel microparticles. Carbohydr Polym. 2018;180:264–75.Google Scholar
- 28.Sharma R, et al. Formulation and in-vitro evaluation of ibuprofen tablet for colonic delivery: optimization of formulation variables using Box-Behnken design. Int J Pharm Sci Res. 2014;5:204–12.Google Scholar
- 29.Alsirawan M, et al. Development and validation of a simple HPLC method for the determination of ibuprofen sticking onto punch faces. J Pharm Pharm Sci. 2013;5(4):227–31.Google Scholar