AAPS PharmSciTech

, Volume 19, Issue 3, pp 1116–1123 | Cite as

Coenzyme Q10-Loaded Fish Oil-Based Bigel System: Probing the Delivery Across Porcine Skin and Possible Interaction with Fish Oil Fatty Acids

  • Mohd Hanif Zulfakar
  • Chan Lee Mei 
  • Khurram Rehman
  • Lam Kok Wai
  • Charles M. Heard
Research Article
  • 94 Downloads

Abstract

Coenzyme Q10 (CoQ10) is a vitamin-like oil-soluble molecule that has anti-oxidant and anti-ageing effects. To determine the most optimal CoQ10 delivery vehicle, CoQ10 was solubilised in both water and fish oil, and formulated into hydrogel, oleogel and bigel. Permeability of CoQ10 from each formulation across porcine ear skin was then evaluated. Furthermore, the effects of the omega-3 fatty eicosapentaenoic (EPA) and docosahexaenoic (DHA) acids from fish oil on skin permeation were investigated by means of nuclear magnetic resonance (NMR) and computerised molecular modelling docking experiments. The highest drug permeation was achieved with the bigel formulation that proved to be the most effective vehicle in delivering CoQ10 across the skin membrane due to a combination of its adhesive, viscous and lipophilic properties. Furthermore, the interactions between CoQ10 and fatty acids revealed by NMR and molecular modelling experiments likely accounted for skin permeability of CoQ10. NMR data showed dose-dependent changes in proton chemical shifts in EPA and DHA. Molecular modelling revealed complex formation and large binding energies between fatty acids and CoQ10. This study advances the knowledge about bigels as drug delivery vehicles and highlights the use of NMR and molecular docking studies for the prediction of the influence of drug–excipient relationships at the molecular level.

KEY WORDS

nuclear magnetic resonance molecular modelling eicosapentaenoic acid docosahexaenoic acid bigel 

Notes

Acknowledgements

The authors would like to thank the Ministry of Education, Malaysia, for providing research grant ERGS/1/2013/SKK02/UKM/02/3 and Faculty of Pharmacy, Universiti Kebangsaan Malaysia, for the additional support during this study.

Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no conflict of interest.

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Copyright information

© American Association of Pharmaceutical Scientists 2017

Authors and Affiliations

  1. 1.Center for Drug Delivery Research, Faculty of PharmacyUniversiti Kebangsaan MalaysiaKuala LumpurMalaysia
  2. 2.Lahore Pharmacy College (A Project of Lahore Medical and Dental College)LahorePakistan
  3. 3.Drug and Herbal Research Centre, Faculty of PharmacyUniversiti Kebangsaan MalaysiaKuala LumpurMalaysia
  4. 4.School of Pharmacy and Pharmaceutical SciencesCardiff UniversityCardiffUK

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