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AAPS PharmSciTech

, Volume 15, Issue 4, pp 1000–1008 | Cite as

Nanoemulsion for Solubilization, Stabilization, and In Vitro Release of Pterostilbene for Oral Delivery

  • Yue Zhang
  • Zhenhua Shang
  • Chunhui Gao
  • Man Du
  • Shixia Xu
  • Haiwen Song
  • Tingting Liu
Research Article

Abstract

Pterostilbene, being extracted from many plants, has significant biological activities in preventing cancer, diabetes, and cardiovascular diseases so as to have great potential applications in pharmaceutical fields. But the poor solubility and stability of pterostilbene strictly restrained its applications. As a good protection and oral delivery system, an optimal nanoemulsion for pterostilbene was developed by using low-energy emulsification method. Systematic pseudo-ternary phase diagrams have been studied in optimization of nanoemulsion formulations. The prepared pterostilbene nanoemulsion was characterized by transmission electron microscope, Fourier transform Raman spectrum, and laser droplet size analyzer. Nanoemulsion droplets are circular with smooth margin, and the mean size is 55.8 ± 10.5 nm. The results illustrated that the nanoemulsion as oral delivery system dramatically improved the stability and solubility of pterostilbene, and in vitro release of pterostilbene was significantly improved (96.5% in pH 3.6 buffer; 13.2% in pH 7.4 buffer) in comparison to the pterostilbene suspension (lower than 21.4% in pH 3.6 buffer; 2.6% in pH 7.4 buffer).

KEY WORDS

3,5-dimethoxyl-4′-hydroxystilbene nanoemulsion pseudo-ternary phase diagram pterostilbene release study 

Notes

Acknowledgments

We express our gratitude for the team fund of Hebei University of Science and Technology (XL201114, QD201211), Hebei Medical and Chemical Engineering Centre, and Pharmaceutical Molecular Chemistry Key Laboratory of Ministry Technology.

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Copyright information

© American Association of Pharmaceutical Scientists 2014

Authors and Affiliations

  • Yue Zhang
    • 1
    • 2
    • 3
  • Zhenhua Shang
    • 1
    • 2
    • 3
  • Chunhui Gao
    • 4
  • Man Du
    • 1
  • Shixia Xu
    • 1
  • Haiwen Song
    • 1
  • Tingting Liu
    • 1
  1. 1.School of Chemical and Pharmaceutical EngineeringHebei University of Science and TechnologyShijiazhuangChina
  2. 2.Hebei Research Center of Pharmaceutical and Chemical EngineeringShijiazhuangChina
  3. 3.State Key Laboratory Breeding Base-Hebei Province Key Laboratory of Molecular Chemistry for DrugsShijiazhuangChina
  4. 4.Zizhu PharmaceuticalQinhuangdaoChina

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