AAPS PharmSciTech

, Volume 14, Issue 4, pp 1303–1312 | Cite as

Molecular Inclusion Complex of Curcumin–β-Cyclodextrin Nanoparticle to Enhance Curcumin Skin Permeability from Hydrophilic Matrix Gel

  • Heni RachmawatiEmail author
  • Citra Ariani Edityaningrum
  • Rachmat Mauludin
Research Article


Curcumin (CUR) has various pharmacological effects, but its extensive first-pass metabolism and short elimination half-life limit its bioavailability. Therefore, transdermal application has become a potential alternative to delivery CUR. To increase CUR solubility for the development of a transparent homogenous gel and also enhance the permeation rate of CUR into the skin, β-cyclodextrin–curcumin nanoparticle complex (BCD–CUR-N) was developed. CUR encapsulation efficiency was increased by raising the percentage of CUR to BCD up to 20%. The mean particle size of the best CUR loading formula was 156 nm. All evaluation data using infrared spectroscopy, Raman spectroscopy, powder X-ray diffractometry, differential thermal analysis and scanning electron microscopy confirmed the successful formation of the inclusion complex. BCD–CUR-N increased the CUR dissolution rate of 10-fold (p < 0.01). In addition, the improvement of CUR permeability acrossed skin model tissue was observed in gel containing the BCD–CUR-N and was about 1.8-fold when compared with the free CUR gel (p < 0.01). Overall, CUR in the form of the BCD–CUR-N improved the solubility further on the penetration of CUR.


β-cyclodextrin curcumin diffusion kinetic hydrophilic gel nanoparticle skin permeation 



This work was financially supported by the Indonesia Managing High Education for Relevance and Efficiency Program, Bandung Institute of Technology 2012.

Conflict of Interest

There is no conflict of interest to declare.


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Copyright information

© American Association of Pharmaceutical Scientists 2013

Authors and Affiliations

  • Heni Rachmawati
    • 1
    Email author
  • Citra Ariani Edityaningrum
    • 1
  • Rachmat Mauludin
    • 1
  1. 1.School of PharmacyBandung Institute of TechnologyBandungIndonesia

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