Molecular Inclusion Complex of Curcumin–β-Cyclodextrin Nanoparticle to Enhance Curcumin Skin Permeability from Hydrophilic Matrix Gel
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Curcumin (CUR) has various pharmacological effects, but its extensive first-pass metabolism and short elimination half-life limit its bioavailability. Therefore, transdermal application has become a potential alternative to delivery CUR. To increase CUR solubility for the development of a transparent homogenous gel and also enhance the permeation rate of CUR into the skin, β-cyclodextrin–curcumin nanoparticle complex (BCD–CUR-N) was developed. CUR encapsulation efficiency was increased by raising the percentage of CUR to BCD up to 20%. The mean particle size of the best CUR loading formula was 156 nm. All evaluation data using infrared spectroscopy, Raman spectroscopy, powder X-ray diffractometry, differential thermal analysis and scanning electron microscopy confirmed the successful formation of the inclusion complex. BCD–CUR-N increased the CUR dissolution rate of 10-fold (p < 0.01). In addition, the improvement of CUR permeability acrossed skin model tissue was observed in gel containing the BCD–CUR-N and was about 1.8-fold when compared with the free CUR gel (p < 0.01). Overall, CUR in the form of the BCD–CUR-N improved the solubility further on the penetration of CUR.
KEY WORDSβ-cyclodextrin curcumin diffusion kinetic hydrophilic gel nanoparticle skin permeation
This work was financially supported by the Indonesia Managing High Education for Relevance and Efficiency Program, Bandung Institute of Technology 2012.
Conflict of Interest
There is no conflict of interest to declare.
- 11.Kazemi F, Zaraghami N, Fekri aval S, Monfaredan A. β-Cyclodextrin–curcumin complex inhibit telomerase gene expression in T47-D breast cancer cell line. African J Biotechnol. 2011;10(83):19481–8.Google Scholar
- 16.Darandale SS, Vavia PR. Cyclodextrin-based nanosponges of curcumin: formulation and physicochemical characterization. J Incl Phenom Macrocycl Chem. 2012;74(1–4):145–55.Google Scholar
- 17.Sourabhan S, Kaladhar K, Sharma CP. Method to enhance the encapsulation of biologically active molecules in PLGA nanoparticles. Trends Biomater Artif Organs. 2009;22(3):211–5.Google Scholar
- 19.Frank CJ. Review of pharmaceutical applications of Raman spectroscopy. In: Pelletier MJ, editor. Analytical applications of Raman spectroscopy. UK: Blackwell Science; 1999. p. 224–71.Google Scholar
- 26.Pugh WJ, Hadgraft J, Roberts MS. Physicochemical determinants of stratum corneum permeation. In: Roberts MS, Walters KA, editors. Dermal absorption and toxicity assessment. New York: Marcel Dekker; 1998. p. 245–68.Google Scholar