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AAPS PharmSciTech

, Volume 14, Issue 4, pp 1321–1332 | Cite as

Comparative Evaluation of Porous Versus Nonporous Mucoadhesive Films as Buccal Delivery System of Glibenclamide

  • Ajay Kumar
  • Vikas Bali
  • Manish Kumar
  • Kamla PathakEmail author
Research Article

Abstract

The present research work focused on the comparative assessment of porous versus nonporous films in order to develop a suitable buccoadhesive device for the delivery of glibenclamide. Both films were prepared by solvent casting technique using the 32 full factorial design, developing nine formulations (F1–F9). The films were evaluated for ex vivo mucoadhesive force, ex vivo mucoadhesion time, in vitro drug release (using a modified flow-through drug release apparatus), and ex vivo drug permeation. The mucoadhesive force, mucoadhesion time, swelling index, and tensile strength were observed to be directly proportional to the content of HPMC K4M. The optimized porous film (F4) showed an in vitro drug release of 84.47 ± 0.98%, ex vivo mucoadhesive force of 0.24 ± 0.04 N, and ex vivo mucoadhesion time of 539.11 ± 3.05 min, while the nonporous film (NF4) with the same polymer composition showed a release of 62.66 ± 0.87%, mucoadhesive force of 0.20 ± 0.05 N, and mucoadhesive time of 510 ± 2.00 min. The porous film showed significant differences for drug release and mucoadhesion time (p < 0.05) versus the nonporous film. The mechanism of drug release was observed to follow non-Fickian diffusion (0.1 < n < 0.5) for both porous and nonporous films. Ex vivo permeation studies through chicken buccal mucosa indicated improved drug permeation in porous films versus nonporous films. The present investigation established porous films to be a cost-effective buccoadhesive delivery system of glibenclamide.

KEY WORDS

buccoadhesive drug delivery glibenclamide in vitro release and ex vivo permeation porous film 

Notes

ACKNOWLEDGMENTS

The authors are thankful to Sun Pharmaceutical Industries Ltd. (Sikkim, India) for providing the gift sample of glibenclamide.

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Copyright information

© American Association of Pharmaceutical Scientists 2013

Authors and Affiliations

  • Ajay Kumar
    • 1
  • Vikas Bali
    • 1
  • Manish Kumar
    • 1
  • Kamla Pathak
    • 1
    Email author
  1. 1.Department of PharmaceuticsRajiv Academy for PharmacyMathuraIndia

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