AAPS PharmSciTech

, Volume 11, Issue 1, pp 351–355

Production and Stability Evaluation of Modified-Release Microparticles for the Delivery of Drug Combinations

Research Article

DOI: 10.1208/s12249-010-9392-1

Cite this article as:
Aamir, M.N. & Ahmad, M. AAPS PharmSciTech (2010) 11: 351. doi:10.1208/s12249-010-9392-1


Production and evaluation of novel formulations of tizanidine and tramadol microparticles was the chief purpose of this project. Microparticles of both drugs were prepared separately via temperature change method. To extend the release of formulations, ethyl cellulose was employed. Higuchi, zero-order, first-order, and Korsmeyer–Peppas kinetic models were applied to appraise the mechanism and mode of drugs release. Higuichi model was found to be best for all release profiles. Stability of microparticles at 40°C/75% RH over a 3-month duration was determined by Fourier transform infrared (FTIR), X-ray diffractometry (XRD), and drugs assay. Microparticles were compatible and stable as no significant differences were observed when subjected to drug assay, FTIR, and XRD during accelerated stability studies.

Key words

microparticles stability evaluation sustained-release (SR) combination tizanidine tramadol 

Copyright information

© American Association of Pharmaceutical Scientists 2010

Authors and Affiliations

  1. 1.Faculty of Pharmacy & Alternative MedicineThe Islamia University of BahawalpurPunjabPakistan

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