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AAPS PharmSciTech

, Volume 10, Issue 2, pp 384–390 | Cite as

Incorporation in Lipid Microparticles of the UVA Filter, Butyl Methoxydibenzoylmethane Combined with the UVB Filter, Octocrylene: Effect on Photostability

  • Santo ScaliaEmail author
  • Matteo Mezzena
Research Article

Abstract

The aim of this study was to reduce the photoinstability of butyl methoxydibenzoylmethane (BMDBM), the most widely used UVA filter, by incorporating it in lipid microparticles (LMs) alone or together with the UVB filter octocrylene (OCR), acting also as photostabilizer. Microparticles loaded with BMDBM or with combined BMDBM and OCR were produced by the hot emulsion technique, using glyceryl behenate as lipid material and poloxamer 188 as surfactant. The LMs were characterized by release studies, scanning electron microscopy, and powder X-ray diffractometry. The BMDBM and OCR loading was 15.2% and 10.6%, respectively. In order to reproduce the conditions prevalent in commercial sunscreen products, the photoprotective efficacy of the LMs was evaluated after their introduction in a model cream (oil-in-water emulsion) containing a mixture of UVA and UVB filters. A small but statistically significant decrease in BMDBM photodegradation was obtained when the UVA filter was encapsulated alone into the LMs (the extent of degradation was 28.6% ±2.4 for non-encapsulated BMDBM and 26.0% ±2.5 for BMDBM-loaded microparticles). On the other hand, the co-loading of OCR in the LMs produced a more marked reduction in the light-induced decomposition of microencapsulated BMDBM (the UVA filter loss was 21.5% ±2.2). Therefore, incorporation in lipid microparticles of BMDBM together with the sunscreen OCR is more effective in enhancing the UVA filter photostability than LMs loaded with BMDBM alone.

Key words

butyl methoxydibenzoylmethane lipid microparticles octocrylene photodegradation sunscreen formulation 

Notes

Acknowledgements

The authors are grateful to MIUR (Ministero dell’Istruzione, dell’Università e della Ricerca, Rome, Italy) for financial support.

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Copyright information

© American Association of Pharmaceutical Scientists 2009

Authors and Affiliations

  1. 1.Department of Pharmaceutical SciencesUniversity of FerraraFerraraItaly
  2. 2.Dipartimento di Scienze FarmaceuticheFerraraItaly

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