AAPS PharmSciTech

, Volume 10, Issue 1, pp 166–171 | Cite as

Improving Tenoxicam Solubility and Bioavailability by Cosolvent System

  • Ming-Kung Yeh
  • Li-Chien Chang
  • Andy Hong-Jey Chiou
Research Article

Abstract

The formulation study of tenoxicam, a poorly water-soluble drug, was developed by use of a ternary cosolvent system and has significantly enhanced the solubility. Additionally, the relative bioavailability of testing formulation was also evaluated by New Zealand rabbit with a single i.m. injection. The three-phase diagram for dimethylsulfoxide (DMSO)/propylene glycol/water, DMSO/ethanol/water, and DMSO/polyethoxylated castor oil/ethanol system was developed. The volume ratio of 5:4:1 in the DMSO/polyethoxylated castor oil/ethanol system resulted in a more suitable vehicle than other systems, with a high solubility (20.73 mg/ml) and low viscosity (10.0 Cp). A pharmacokinetic study of bioequivalence (F rel = 0.89) was also obtained. The present study not only provides a novel strategy improving tenoxicam solubility but also helps further scientific knowledge for the development of parenteral formulations.

Key words

bioavailability cosolvent system pharmacokinetics poorly water-soluble drug solubility tenoxicam 

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Copyright information

© American Association of Pharmaceutical Scientists 2009

Authors and Affiliations

  • Ming-Kung Yeh
    • 1
  • Li-Chien Chang
    • 2
  • Andy Hong-Jey Chiou
    • 3
  1. 1.Department of Pharmacy PracticeTri-Service General HospitalTaipeiTaiwan
  2. 2.School of PharmacyNational Defense Medical CenterTaipeiTaiwan
  3. 3.Institute of Preventive MedicineNational Defense Medical CenterTaipeiRepublic of China

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