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The AAPS Journal

, Volume 14, Issue 4, pp 688–702 | Cite as

Engineered Nanoparticulate Drug Delivery Systems: The Next Frontier for Oral Administration?

  • Roudayna DiabEmail author
  • Chiraz Jaafar-Maalej
  • Hatem Fessi
  • Philippe Maincent
Review Article Theme: Develop Enabling Technologies for Delivering Poorly Water Soluble Drugs: Current Status and Future Perspectives

Abstract

For the past few decades, there has been a considerable research interest in the area of oral drug delivery using nanoparticle (NP) delivery systems as carriers. Oral NPs have been used as a physical approach to improve the solubility and the stability of active pharmaceutical ingredients (APIs) in the gastrointestinal juices, to enhance the intestinal permeability of drugs, to sustain and to control the release of encapsulated APIs allowing the dosing frequency to be reduced, and finally, to achieve both local and systemic drug targeting. Numerous materials have been used in the formulation of oral NPs leading to different nanoparticulate platforms. In this paper, we review various aspects of the formulation and the characterization of polymeric, lipid, and inorganic NPs. Special attention will be dedicated to their performance in the oral delivery of drug molecules and therapeutic genes.

KEY WORDS

biodegradable nanoparticles natural oral polymer 

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Copyright information

© American Association of Pharmaceutical Scientists 2012

Authors and Affiliations

  • Roudayna Diab
    • 1
    Email author
  • Chiraz Jaafar-Maalej
    • 2
  • Hatem Fessi
    • 2
  • Philippe Maincent
    • 1
  1. 1.Pharmaceutical Technology Group, CITHÉFOR EA 3452, Faculty of PharmacyUniversity of LorraineNancy CedexFrance
  2. 2.Pharmaceutical Technology Group, LAGEP, UMR CNRS 5007, ISPBL-Faculty of PharmacyUniversity of LyonVilleurbanneFrance

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