The AAPS Journal

, Volume 12, Issue 3, pp 263–271 | Cite as

DDSolver: An Add-In Program for Modeling and Comparison of Drug Dissolution Profiles

  • Yong Zhang
  • Meirong Huo
  • Jianping Zhou
  • Aifeng Zou
  • Weize Li
  • Chengli Yao
  • Shaofei Xie
Research Article

Abstract

In recent years, several mathematical models have been developed for analysis of drug dissolution data, and many different mathematical approaches have been proposed to assess the similarity between two drug dissolution profiles. However, until now, no computer program has been reported for simplifying the calculations involved in the modeling and comparison of dissolution profiles. The purposes of this article are: (1) to describe the development of a software program, called DDSolver, for facilitating the assessment of similarity between drug dissolution data; (2) to establish a model library for fitting dissolution data using a nonlinear optimization method; and (3) to provide a brief review of available approaches for comparing drug dissolution profiles. DDSolver is a freely available program which is capable of performing most existing techniques for comparing drug release data, including exploratory data analysis, univariate ANOVA, ratio test procedures, the difference factor f1, the similarity factor f2, the Rescigno indices, the 90% confidence interval (CI) of difference method, the multivariate statistical distance method, the model-dependent method, the bootstrap f2 method, and Chow and Ki’s time series method. Sample runs of the program demonstrated that the results were satisfactory, and DDSolver could be served as a useful tool for dissolution data analysis.

Key words

computer program DDSolver dissolution similarity drug dissolution drug-release model 

Supplementary material

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12248_2010_9185_MOESM2_ESM.zip (7.6 mb)
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12248_2010_9185_MOESM3_ESM.xls (220 kb)
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12248_2010_9185_MOESM4_ESM.doc (369 kb)
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Copyright information

© American Association of Pharmaceutical Scientists 2010

Authors and Affiliations

  • Yong Zhang
    • 1
  • Meirong Huo
    • 1
  • Jianping Zhou
    • 1
  • Aifeng Zou
    • 1
  • Weize Li
    • 1
  • Chengli Yao
    • 1
  • Shaofei Xie
    • 2
  1. 1.Department of PharmaceuticsChina Pharmaceutical UniversityNanjingChina
  2. 2.Key Laboratory of Drug Quality Control and Pharmacovigilance, Ministry of Education, Center for Instrumental AnalysisChina Pharmaceutical UniversityNanjingChina

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