The AAPS Journal

, Volume 11, Issue 3, pp 495–510 | Cite as

Curcumin and Cancer Cells: How Many Ways Can Curry Kill Tumor Cells Selectively?

  • Jayaraj Ravindran
  • Sahdeo Prasad
  • Bharat B. Aggarwal
Review Article Theme: Natural Products as Therapeutic Modulators

Abstract

Cancer is a hyperproliferative disorder that is usually treated by chemotherapeutic agents that are toxic not only to tumor cells but also to normal cells, so these agents produce major side effects. In addition, these agents are highly expensive and thus not affordable for most. Moreover, such agents cannot be used for cancer prevention. Traditional medicines are generally free of the deleterious side effects and usually inexpensive. Curcumin, a component of turmeric (Curcuma longa), is one such agent that is safe, affordable, and efficacious. How curcumin kills tumor cells is the focus of this review. We show that curcumin modulates growth of tumor cells through regulation of multiple cell signaling pathways including cell proliferation pathway (cyclin D1, c-myc), cell survival pathway (Bcl-2, Bcl-xL, cFLIP, XIAP, c-IAP1), caspase activation pathway (caspase-8, 3, 9), tumor suppressor pathway (p53, p21) death receptor pathway (DR4, DR5), mitochondrial pathways, and protein kinase pathway (JNK, Akt, and AMPK). How curcumin selectively kills tumor cells, and not normal cells, is also described in detail.

KEY WORDS

apoptosis cancer curcumin molecular targets signaling pathways. 

Notes

ACKNOWLEDGMENTS

We thank Walter Pagel for carefully proofreading the manuscript and providing valuable comments. Dr. Aggarwal is Ransom Horne, Jr., Professor of Cancer Research. This work was supported by a grant from the Clayton Foundation for Research (B.B.A.), a core grant from the National Institutes of Health (CA-16 672), a program project grant from National Institutes of Health (NIH CA-124787-01A2), and grant from Center for Targeted Therapy of M.D. Anderson Cancer Center.

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Copyright information

© American Association of Pharmaceutical Scientists 2009

Authors and Affiliations

  • Jayaraj Ravindran
    • 1
  • Sahdeo Prasad
    • 1
  • Bharat B. Aggarwal
    • 1
  1. 1.Cytokine Research Laboratory, Department of Experimental TherapeuticsThe University of Texas M. D. Anderson Cancer CenterHoustonUSA

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