The AAPS Journal

, Volume 10, Issue 3, pp 494–503 | Cite as

Surface Energy of Microcrystalline Cellulose Determined by Capillary Intrusion and Inverse Gas Chromatography

  • D. Fraser Steele
  • R. Christian Moreton
  • John N. Staniforth
  • Paul M. Young
  • Michael J. Tobyn
  • Stephen Edge
Research Article


Surface energy data for samples of microcrystalline cellulose have been obtained using two techniques: capillary intrusion and inverse gas chromatography. Ten microcrystalline cellulose materials, studied using capillary intrusion, showed significant differences in the measured surface energetics (in terms of total surface energy and the acid–base characteristics of the cellulose surface), with variations noted between the seven different manufacturers who produced the microcrystalline cellulose samples. The surface energy data from capillary intrusion was similar to data obtained using inverse gas chromatography with the column maintained at 44% relative humidity for the three samples of microcrystalline cellulose studied. This suggests that capillary intrusion may be a suitable method to study the surface energy of pharmaceutical samples.

Key words

capillary intrusion dynamic contact angle excipient inverse gas chromatography microcrystalline cellulose surface energy 


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Copyright information

© American Association of Pharmaceutical Scientists 2008

Authors and Affiliations

  • D. Fraser Steele
    • 1
    • 4
  • R. Christian Moreton
    • 2
  • John N. Staniforth
    • 1
  • Paul M. Young
    • 3
  • Michael J. Tobyn
    • 1
  • Stephen Edge
    • 1
  1. 1.Pharmaceutical Technology Research Group, Department of Pharmacy & PharmacologyUniversity of BathBathUK
  2. 2.FinnBrit ConsultingWalthamUSA
  3. 3.Advanced Drug Delivery GroupUniversity of SydneySydneyAustralia
  4. 4.Drug Delivery Solutions LtdLeatherhead Enterprise CentreLeatherheadUK

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