AAPS PharmSciTech

, 7:E172

Design and development of microemulsion drug delivery system of acyclovir for improvement of oral bioavailability

  • Pradip Kumar Ghosh
  • Rita J. Majithiya
  • Manish L. Umrethia
  • Rayasa S. R. Murthy
Article

DOI: 10.1208/pt070377

Cite this article as:
Ghosh, P.K., Majithiya, R.J., Umrethia, M.L. et al. AAPS PharmSciTech (2006) 7: E172. doi:10.1208/pt070377

Abstract

The main purpose of this work was to develop an oral microemulsion formulation for enhancing the bioavailability of acyclovir. A Labrafac-based microemulsion formulation with Labrasol as surfactant and Plurol Oleique as cosurfactant was developed for oral delivery of acyclovir. Phase behavior and solubilization capacity of the microemulsion system were characterized, and in vivo oral absorption of acyclovir from the microemulsion was investigated in rats. A single isotropic region, which was considered to be a bicontinuous microemulsion, was found in the pseudoternary phase diagrams developed at various Labrasol:Plurol Oleique:Labrafac ratios. With the increase of Labrasol concentration, the microemulsion region area and the amount of water and Labrafac solubilized into the microemulsion system increased; however, the increase of Plurol Oleique percentage produced opposite effects. The microemulsion system was also investigated in terms of other characteristics, such as interfacial tension, viscosity, pH, refractive index, diffusion, and bioavailability. Acyclovir, a poorly soluble drug, displayed high solubility in a microemulsion formulation using Labrafac (10%). Labrasol (32%), Plurol Oleique (8%), and water (50%). The in vitro intraduodenal diffusion and in vivo study revealed an increase of bioavailability (12.78 times) after oral administration of the microemulsion formulation as compared with the commercially available tablets.

Keywords

Microemulsion non-ionic surfactant conductivity interfacial tension particle size 

Copyright information

© American Association of Pharmaceutical Scientists 2006

Authors and Affiliations

  • Pradip Kumar Ghosh
    • 1
  • Rita J. Majithiya
    • 1
  • Manish L. Umrethia
    • 1
  • Rayasa S. R. Murthy
    • 1
  1. 1.Drug Delivery Research LaboratoryMS University of Baroda, Pharmacy DepartmentVadodaraIndia

Personalised recommendations