AAPS PharmSciTech

, 4:1

Synergistic effect of PEG-400 and cyclodextrin to enhance solubility of progesterone

  • Indranil Nandi
  • Michelle Bateson
  • Mohammad Bari
  • Hemant N. Joshi


PEG-400, polysorbate 80, and 2 CDs (Trappsol HPB and Captisol) were used in an attempt to improve the aqueous solubility of a model hydrophobic drug, progesterone. The aqueous solubility of progesterone improved significantly from 0.007 mg/mL by the addition of PEG-400, CDs, and polysorbate 80. In systems containing various amounts of PEG-400 and 3% Trappsol HPB in water (% wt/wt), the theoretical solubility was calculated by adding the solubilities in the individual systems. The observed solubility values were up to 96% higher than the theoretical values. The effect of synergism was significant in 5% to 50% PEG-400/water systems containing Trappsol HPB. Systems containing Captisol did not show such synergistic effects. In general, the addition of polysorbate 80 to the PEG-400/water systems containing CDs affected synergism negatively.


cosolvent cyclodextrins PEG-400 progesterone solubilization synergism 

Copyright information

© American Association of Pharmaceutical Scientists 2003

Authors and Affiliations

  • Indranil Nandi
    • 1
  • Michelle Bateson
    • 2
  • Mohammad Bari
    • 3
  • Hemant N. Joshi
    • 4
  1. 1.Geneva Pharmaceutical Technology CorpDayton
  2. 2.Galen LimitedLarneNorthern Ireland
  3. 3.Forest Laboratories IncInwood
  4. 4.Barr LaboratoriesPharmaceutical Research & DevelopmentPomona

Personalised recommendations