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AAPS PharmSci

, Volume 2, Issue 1, pp 48–58 | Cite as

Targeted prodrug design to optimize drug delivery

  • Hyo-Kyung Han
  • Gordon L. Amidon
Article

Abstract

Classical prodrug design often represents a nonspecific chemical approach to mask undesirable drug properties such as limited bioavailability, lack of site specificity, and chemical instability. On the other hand, targeted prodrug design represents a new strategy for directed and efficient drug delivery. Particularly, targeting the prodrugs to a specific enzyme or a specific membrane transporter, or both, has potential as a selective drug delivery system in cancer chemotherapy or as an efficient oral drug delivery system. Site-selective targeting with prodrugs can be further enhanced by the simultaneous use of gene delivery to express the requisite enzymes or transporters. This review highlights evolving strategies in targeted prodrug design, including antibody-directed enzyme prodrug therapy, genedirected enzyme prodrug therapy, and peptide transporter-associated prodrug therapy.

Keywords

Peptide Transporter Amidon Palytoxin Oral Drug Absorption Enzyme Prodrug Therapy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© American Association of Pharmaceutical Scientists 2002

Authors and Affiliations

  1. 1.Parke-Davis Pharmaceutical Research, Division of Warner-LambertDepartment of Pharmacokinetics, Dynamics and MetabolismAnn ArborUSA
  2. 2.College of PharmacyThe University of MichiganAnn Arbor

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