Differential diagnosis of chronic fatigue syndrome and major depressive disorder
- 220 Downloads
The goal of this study was to identify variables that successfully differentiated patients with chronic fatigue syndrome, major depressive disorder, and controls. Fifteen participants were recruited for each of these three groups, and discriminant function analyses were conducted. Using symptom occurrence and severity data from the Fukuda et al. (1994) definitional criteria, the best predictors were postexertional malaise, unrefreshing sleep, and impaired memory-concentration. Symptom occurrence variables only correctly classified 84.4% of cases, whereas 91.1% were correctly classified when using symptom severity ratings. Finally, when using percentage of time fatigue reported, postexertional malaise severity, unrefreshing sleep severity, confusion-disorientation severity, shortness of breath severity, and self-reproach to predict group membership, 100% were classified correctly.
Key wordschronic fatigue syndrome depression symptomatology diagnostic criteria
Unable to display preview. Download preview PDF.
- Carruthers, B. M., Jain, A. K., DeMeirleir, K. L., Peterson, D. L., Klimas, N. G., Lerner, A. M., et al. (2003). Myalgic encephalomyelitis/chronic fatigue syndrome: Clinical working case definition, diagnostic and treatments protocols. Journal of Chronic Fatigue Syndrome, 11, 7–115.CrossRefGoogle Scholar
- Hawk, C., Jason, L. A., & Peña, J. (2006). ACTRE variables that differentiate chronic fatigue syndrome from depression. Manuscript submitted for publication.Google Scholar
- Huber, S., Rammonhan, K., Bornstein, R., & Christy, J. (1993). Depressive symptoms are not influenced by severity of multiple sclerosis. Neuropsychology, Neuropsychiatry, and Behavioral Neurology, 6, 177–180.Google Scholar
- Jason, L. A., Fennell, P., & Taylor, R. R. (Eds.). (2003). Handbook of chronic fatigue syndrome. New York: Wiley.Google Scholar
- Spitzer, R. L., Williams, J. B. W., Gibbon, M., & First, M. B. (1995). Structured clinical interview for the DSM-IV: Non-Patient Edition (SCID: NP, Version 2.0). Washington, DC: American Psychiatric Press.Google Scholar
- Stouten, B. (2005). Identification of ambiguities in the 1994 chronic fatigue syndrome research case definition and recommendations for resolution. BMC Health Services Research 2005, 5:37 doi:10.1186/1472–6963–5–37.Google Scholar
- Wasser, T. E. (1991, August). Statistical correction of Hollinghead’s four factor index of social status. Paper presented at the American Psychological Association, San Francisco, CA.Google Scholar