Abstract
This study examined differences in plasma epinephrine (EPI) and norepinephrine (NOREPI) responses to stressors in 67 healthy African-American and Caucasian American men and women of the ages 18 to 49. Subjects were divided into three groups: (a) those who showed high blood pressure (BP) responses to stress associated with consistently high cardiac output (CO) increases with no substantial increases in total peripheral resistance (TPR), labeled cardiac reactors; (b) those with equally high BP increases associated with consistently higher TPR increases and lesser CO increases, labeled vascular reactors; (c) those who showed mixed hemodynamic responses or were low BP reactors. Ethnic and gender group differences in EPI and NOREPI responses were also examined. Cardiac reactors, vascular reactors and mixed + low reactors did not differ in EPI or NOREPI levels at baseline. During stressors, cardiac reactors showed greater increases in plasma EPI than vascular reactors or others during math, reaction time, and passive and active speech tasks; they also showed a weak trend toward greater NOREPI increases during these challenges as well. No differences were seen during the cold pressor; this stressor evoked the least change in EPI of all tasks, whereas the active speech elicited the greatest increases in both EPI and NOREPI of all tasks. Vascular reactors did not differ from mixed + low reactors in EPI or NOREPI reactivity, and men and women did not differ in EPI or NOREPI reactivity to any task. In contrast. Black subjects showed greater increases in NOREPI levels across all stressors compared to White subjects. These findings have implications for investigations of the role of sympathetic nervous system activity in the pathogenesis of hypertension in both African-American and Caucasian American populations.
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Anderson, N. B., Lane. J. D., Muranaka, M., Williams, R. B., & Houseworth S. J. (1988). Racial differences in blood pressure and forearm vascular responses to the cold face stimulus. Psychosomatic Medicine. 50, 57–63.
Bolli, P., Erne, P., Block, L. H., Ji. B. H., Kiowski, W., & Buhler. F. R. (1984). Adrenaline induces vasoconstriction through postjunctional alpha-2 adrenoceptro stimulation which is enhanced in essential hypertension. Journal of Hypertension, 2(Suppt. 3), 115–118.
Dimsdale, J. E., Ziegler, M., Mills. P., Delehanty. S. G.,& Berry, C. (1990). Effects of salt, race. and hypertension on reactivity to stressors. Hypertension, 16, 573–580.
Esler, M., Jennings, G., Biviano, B., Lambert, G. & Hasking, G. (1986). Mechanism of elevated plasma noradrenaline in the course of essential hypertension, Journal of Cardiovascular Pharmacology, 8(Suppl. 5), S39-S43.
Frankenhaeuscr, M. (1983). The sympathetic-adrenal and pituitary-adrenal response to challenge: Comparison between the sexes. In T. M. Dembroski, T. Schmidt, & G. Blumchen (Eds.), Biobehavioral bases of coronary heart disease (pp. 91–105). New York: Karger.
Girdler, S. S., Hinderiiter, A. L., & Light, K. C. (1993). Peripheral adrenergic receptor contributions to cardiovascular reactivity: Influence of race and gender. Journal of Psychosomatic Research, 37, 177–193.
Goldstein, D. S. (1983). Plasma catecholamines and essential hypertension: An analytical review. Hypertension. 5, 86–99.
Hjemdahl, P., Freyschuss, U., Juhlin-Dannfelt. A., & Linde, B. (1984). Differentiated sympathetic activation during mental stress evoked by the Stroop test. Acta Physiologica Scandinavica (Suppl. 527), 25–29.
Jie, K., Van Brummelen, P., Vermey, P., Timmermans, P. B. M. W. M., & van Zwielen. P. A. (1984). Effects of exogenous adrenaline and noradrenaline on vascular alpha-l and alpha-2 adrenoceptors in man. Journal of Hypertension, 2 (Suppl. 3), 119–121.
Julius, S. (1988). The blood pressure seeking properties of the central nervous system. Journal of Hypertension. 6, 177–185.
Julius, S. (1993). Sympathetic hyperactivity and coronary risk in hypertension. Hypertension. 21, 886–893.
Julius, S., Krause. L., Schork, N. J., Mejia, A. D., Jones, K, A., van de Ven, C., Johnson, E. H., Sekkarie, M A., Kjeldsen, S. E., Petrin, J., Schmouder, R., Gupta, R., Ferraro, J., Nazzaro, P., & Weissfeld, J. (1991). Hyperkinetic borderline hypertension in Tecumseh, Michigan. Journal of Hypertension. 9, 77–84.
Kamarck, T. W., Jennings, J. R., Stewart, C. J., & Eddy. M. J. (1993). Reliable responses to a cardiovascular reactivity protocol: A replication study in a biracial female sample. Psychophysiology, 30, 627–634.
Kasprowicz, A. L., Manuck, S.B., Malkoff, S. B., & Krantz, D. S. (1990). Individual differences in behaviorally evoked cardiovascular response: Temporal stability and hemodynamic patterning. Psychophysiology. 7, 605–619.
Kjeldsen, S. E., Petrin, J., Weder, A. B., & Julius, S. (1993), Contrasting effects of epinephrine on forearm hemodynamics and arterial norepinephrine. American Journal of Hypertension. 6, 369–375,
Korner, P. I., Bobik. A., Jennings, G, L., Angus, J. A., & Anderson, W. P. (1991). Significance of cardiovascular hypertrophy in the development and maintenance of hypertension. Journal of Cardiovascular Pharmacology, 17(Suppl 2), S25-S32.
Leenen. F. H. H., Chan, Y. K., Smith, D. L., & Reeves, R. A. (1988), Epinephrine and left ventricular function in humans: Effects of beta-1 vs. nonselective beta-blockade. Clinical Pharmacology A Therapeutics, 43, 519–528.
Lever, A. F. (1986). Slow pressor mechanisms in hypertension: A role for hypertrophy of resistance vessels? Journal of Hypertension. 4, 515–524,
Light, K. C., Dolan. C. A., Davis, M. R., & Sherwood, A. (1992) Cardiovascular responses to an active coping challenge as predictors of blood pressure patterns 10 to 15 years later. Psychosomatic Medicine. 54, 217–230.
Light, K. C., & Sherwood, A. (1989). Race, borderline hypertension, and hemodynamic responses to behavioral stress before and after beta-adrenergic blockade. Health Psychology, 8, 577–595.
Light, K. C., Turner, J. R., Hinderliter, A. L., & Sherwood, A. (1993). Race and gender comparisons; I. Hemodynamic responses to a scries of stressors. Health Psychology. 12, 354–365.
Lund-Johansen, P. (1989). Central hemodynamics in essential hypertension at rest and during exercise: A 20 year follow-up study. Journal of Hypertension. 7(Suppl. 6), S52-S55.
Manuck, S. B. (1994). Cardiovascular reactivity in cardiovascular disease: “Once more unto the breach”. International Journal of Behavioral Medicine, 1, 4–31.
Manuck, S. B., Kasprowicz, A. L., & Muldoon, M. F. (1990). Behaviorally evoked cardiovascular reactivity and hypertension: Conceptual issues and potential associations. Annals of Behavioral Medicine, 12, 17–29.
Matthews, K. A., Woodall, K. L., & Allen. M, T. (1993). Cardiovascular reactivity to stress predicts future blood pressure status. Hypertension, 22, 479–485.
Menkes, M. S., Matthews. K. A., Krantz, D. S., Lundberg, U., Mead, L. A., Qaqish, B., Liang, K. Y., Thomas, C. B., & Pearson, T. A. (1989). Cardiovascular reactivity to the cold pressor test as a predictor of hypertension. Hypertension, 14, 524–530.
Pickering, T. G., & Gerin, W. (1990). Cardiovascular reactivity in the laboratory and the role of behavioral factors in hypertension: A critical review. Annuls of Behavioral Medicine. 12, 3–16.
Rizzoni, D., Castellano, M., Porteri, E., Beltoni, G., Muiesan, M. L., & Agabiti-Rosei, E. (1994). Vascular structural and functional alterations before and after the development of hypertension in SHR. American Journal of Hypertension, 7, 193–200,
Saab, P. G., Llabre, M. M., Hurwitz, B. E., Frame, C. A., Reineke, L. J., Fins, A. L., McCalla. J., Cieply, L. K., & Schneiderman, N. (1992). Myocardial and peripheral vascular responses to behavioral challenges and their stability in Black and White Americans, Psychophysiology. 29, 384–397.
Saab, P. G., Llabre. M. M., Hurwitz, B. E., Schneiderman. N., Wohlgemuth, W., Durel, L. A., Massie, C., & Nagel, J. (1993). The cold pressor test: Vascular and myocardial response patterns and their stability. Psychnphysiology, 30, 366–373.
Sager. A. R., Hinderliter, A. L., Light, K. C., Sherwood, A., & Willis. P. W.. IV. (1994), Ethnic differences in forearm vasodilator capacity. Manuscript submitted For publication.
Sherwood, A., Allen, M. T., Fahrenberg, J., Kelsey, R. M., Lovallo. W. R., & van Doornen, L, J. P. (1990). Committee report: Methodological guidelines for impedance cardiography. Psychophysiology, 27, 1–23.
Sherwood, A., Allen, M. T., Obrist, P. A., & Langer, A. W. (1986). Evaluation of beta-adrenergic influences on cardiovascular and metabolic adjustments to physical and psychological stress. Psychophysiology. 23, 89–104.
Sherwood, A., Dolan, C. A., & Light, K. C. (1990). Hemodynamics of blood pressure responses during active and passive coping. Psychophysiology, 27, 656–668.
Sherwood. A., & Hinderliter, A. L. (1993). Responsiveness to alpha- and beta-adrenergic receptor agonists: Effects of race in borderline hypertensive compared to normotensive men. American Journal of Hypertension, 6, 630–635.
Stoney, C. M., Davis, M. C., & Malthews, K. A. (1987). Sex differences in physiological responses to stress and in coronary heart disease: A causal link? Psychophysiology, 24, 127–131.
Stoney, C. M., Matthews. K. A., MacDonald. R. H., & Johnson, C. A. (1988). Sex differences in lipid, lipoprotein, cardiovascular and neuroendocrine responses to acute stress. Psychophysiology. 25, 645–656.
Tischenkel, N. J., Saab, P. G., Schneiderman, N., Nelson, R. A., Pasin, R. D., Goldstein. D. A., Spitzer, S. B., Woo-Ming, R., & Weidler, D. J. (1989) Cardiovascular and neurohumoral responses to behavioral challenge as a function of race and sex. Health Psychology, 8, 503–524.
Treiber, F. A., Musante, L., Braden, D., Arensman, F., Strong, W. B., Levey, M., & Leverett, S. (1990). Racial differences in hemodynamic responses to the cold face stimulus in children and adults. Psychosomatic Medicine. 52, 286–296.
Turner, J. R., Sherwood, A., & Light, K. C. (1994). Intertask consistency of hemodynamic responses to laboratory stressors in a biracial sample of men and women. International Journal of Psychophysiology. 17, 159–164.
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This research was supported by National Institutes of Health Grants R01 HL31533, RR00046,
This research was supported by National Institutes of Health Grants R01 HL31533, RR00046,
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Light, K.C., Turner, J.R., Hinderliter, A.L. et al. Comparison of cardiac versus vascular reactors and ethnic groups in plasma epinephrine and norepinephrine responses to stress. Int. J. Behav. Med. 1, 229–246 (1994). https://doi.org/10.1207/s15327558ijbm0103_4
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DOI: https://doi.org/10.1207/s15327558ijbm0103_4