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Interactive effects of anger expression and ET-1 Lys198Asn polymorphism on vasoconstriction reactivity to behavioral stress

  • Published:
Annals of Behavioral Medicine

Abstract

Background: Ineffective anger expression has been associated with essential hypertension (EH) and with blood pressure (BP) reactivity to stress. The ET-1/Lys198Asn polymorphism has been associated with increased resting BP and exaggerated vasoconstrictive mediated BP reactivity. African Americans (AAs) are at particular risk for development of EH, report greater anger difficulties, and exhibit greater vasoconstrictive reactivity than their European American (EA) counterparts.Purpose: The objective is to investigate a gene-environment model of stress reactivity in which anger expression, particularly in combination with ET-1 T allele carrier status and AA ethnicity, would be associated with the greatest vasoconstrictive reactivity in response to a behavioral stressor.Methods: One hundred ninety-one AA and 197 EA normotensive young adults (Mage=18.8±2.5 years) participated in the study. Total peripheral resistance index (TPRI) reactivity was assessed during a 10-min video game challenge. Anger expression was measured using Spielberger’s Anger Expression Scale.Results: A multiple regression model with TPRI reactivity as the dependent variable revealed a three-way interaction effect for anger management (i.e., AM=anger control minus anger out scores), ethnicity, and ET-1 polymorphism. Specifically, AA carriers of the ET-1 polymorphism with poor AM skills exhibited the greatest TPRI reactivity.Conclusions: Individuals with a genetic predisposition for exaggerated vasoconstriction who also display low AM skills may be at particular risk for development of stress-induced EH. Such individuals may particularly benefit from anger management training.

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References

  1. Spielberger CD:State-Trait Anger Expression Inventory: Professional Manual. Odessa, FL, Psychological Assessment Resources, 1996.

    Google Scholar 

  2. Williams JE, Paton CC, Siegler IC, et al.: Anger proneness predicts coronary heart disease risk: Prospective analysis from the atherosclerotic risk in communities (ARIC) study.Circulation. 2000,101:2034–2039.

    PubMed  CAS  Google Scholar 

  3. Johnson EH (ed):The Deadly Emotions: The Role of Anger, Hostility, and Aggression in Health and Emotional Well-Being. New York, Praeger, 1990.

    Google Scholar 

  4. Friedman R, Schwartz JE, Schnall PL, et al.: Psychological variables in hypertension: Relationship to causal or ambulatory blood pressure in men.Psychosomatic Medicine. 2003,63:19–31.

    Google Scholar 

  5. Porter LS, Stone AA, Schwartz JE: Anger expression and ambulatory blood pressure: A comparison of state and trait measures.Psychosomatic Medicine. 1999,61:454–463.

    PubMed  CAS  Google Scholar 

  6. Hauber RP, Rice MH, Howell CC, Carmon M: Anger and blood pressure readings in children.Applied Nursing Research. 1998,11:2–11.

    Article  PubMed  CAS  Google Scholar 

  7. Rutledge T, Hogan BE: A quantitative review of prospective evidence linking psychological factors with hypertension development.Psychosomatic Medicine. 2002,64:758–766.

    Article  PubMed  Google Scholar 

  8. Everson SA, Goldberg DE, Kaplan GA: Anger expression and incident hypertension.Psychosomatic Medicine. 1998,60:730–735.

    PubMed  CAS  Google Scholar 

  9. Jorgensen RS, Johnson BT, Kolodziej ME, Schreer GE: Elevated blood pressure and personality: A meta-analytic review.Psychological Bulletin. 1996,120:293–320.

    Article  PubMed  CAS  Google Scholar 

  10. Snieder H, Harshfield GA, Barbeau P, et al.: Dissecting the genetic architecture of the cardiovascular and renal stress response.Biological Psychology. 2002,61:73–95.

    Article  PubMed  Google Scholar 

  11. Anderson NB, McNeilly M, Myers H: Autonomic reactivity and hypertension in blacks: A review and proposed model.Ethnicity and Disease. 1991,1:154–170.

    PubMed  CAS  Google Scholar 

  12. Burt VL, Whelton P, Roccella EJ, et al.: Prevalence of hypertension in the US adult population: Results from the Third National Health and Nutrition Examination Survey, 1988–1991.Hypertension. 1995,25:305–313.

    PubMed  CAS  Google Scholar 

  13. Lawler KA, Kline N, Seabrook E, et al.: Family history of hypertension: A psychophysiological analysis.International Journal of Psychophysiology. 1998,28:207–222.

    Article  PubMed  CAS  Google Scholar 

  14. Vogele C, Steptoe A: Anger inhibition and family history as modulators of cardiovascular responses to mental stress in adolescent boys.Journal of Psychosomatic Research. 1993,37:503–514.

    Article  PubMed  CAS  Google Scholar 

  15. Pausova Z, Tremblay J, Hamet J: Gene-environment interactions in hypertension.Pathogenesis of Hypertension. 1999,1:42–50.

    CAS  Google Scholar 

  16. Vane JR, Anggard EE, Botting RM: Regulatory functions of the vascular endothelium.New England Journal of Medicine. 1990,323:27–36.

    PubMed  CAS  Google Scholar 

  17. Schiffrin EL, Thibault G: Plasma endothelin in human essential hypertension.American Journal of Hypertension. 1991,4:303–308.

    PubMed  CAS  Google Scholar 

  18. Schneider MP, Hilgers KF, Klingbeil AU, et al.: Plasma endothelin is increased in early essential hypertension.American Journal of Hypertension. 2000,13:579–585.

    Article  PubMed  CAS  Google Scholar 

  19. Treiber FA, Kapuku GK, Davis H, Pollock JS, Pollock DM: Plasma endothelin-1 release during acute stress: role of ethnicity and sex.Psychosomatic Medicine. 2002,64:707–713.

    Article  PubMed  CAS  Google Scholar 

  20. Evans RR, Phillips BG, Singh G, Bauman JL, Gulati A: Racial and gender differences in endothelin-1.American Journal of Cardiology. 1996,78:486–488.

    Article  PubMed  CAS  Google Scholar 

  21. Tiret L, Poirier O, Hallet V, et al.: The Lys198Asn polymorphism in the endothelin-1 gene is associated with blood pressure in overweight people.Hypertension. 1999,33:1169–1174.

    PubMed  CAS  Google Scholar 

  22. Asai T, Ohkubo T, Katsuya T, et al.: Endothelin-1 gene variant associates with blood pressure in obese Japanese subjects: the Ohasama Study.Hypertension. 2001,38:1321–1324.

    Article  PubMed  CAS  Google Scholar 

  23. Treiber FA, Barbeau P, Harshfield G, et al.: Endothelin-1 gene Lys198Asn polymorphism and blood pressure reactivity.Hypertension. 2003,42:494–499.

    Article  PubMed  CAS  Google Scholar 

  24. Johnson EH: The role of the experience and expression of anger and anxiety in elevated blood pressure among Black and White adolescents.Journal of the National Medical Association. 1989,81:584.

    Google Scholar 

  25. Barefoot JC, Peterson BL, Dahlstrom WG, et al.: Hostility patterns and implications: Correlates of Cook-Medley Hostility Scale scores in a national survey.Health Psychology. 1991,10:18–24.

    Article  PubMed  CAS  Google Scholar 

  26. Rosner BA, Appel LJ, Raczynski JM, et al.: A comparison of two automated monitors in the measurement of blood pressure reactivity.Annals of Epidemiology. 1990,1:57–69.

    Article  PubMed  CAS  Google Scholar 

  27. Jackson RW, Snieder H, Davis H, Treiber FA: Determination of twin zygosity: A comparison of DNA with various questionnaire indices.Twin Research. 2001,4:12–18.

    Article  PubMed  CAS  Google Scholar 

  28. Musante L, Treiber FA, Davis HC, Waller JL, Thompson WO: Assessment of self-reported anger expression in youth.Assessment. 1999,6:225–234.

    Article  PubMed  CAS  Google Scholar 

  29. Musante L, Turner JR, Treiber FA, Davis H, Strong WB: Moderators of ethnic differences in vasoconstrictive reactivity in youth.Ethnicity and Disease. 1996,6:224–234.

    PubMed  CAS  Google Scholar 

  30. Treiber FA, Jackson RW, Davis H, et al.: Racial differences in Endothelin-1 at rest and in response to acute stress in adolescent males.Hypertension. 2000,35:722–725.

    PubMed  CAS  Google Scholar 

  31. Musante L, Treiber FA: The relationship between anger-coping styles and lifestyle behaviors in teenagers.Journal of Adolescent Health. 2000,27:63–68.

    Article  PubMed  CAS  Google Scholar 

  32. Light KC: Hypertension and the reactivity hypothesis: The next generation.Psychosomatic Medicine. 2001,63:744–746.

    PubMed  CAS  Google Scholar 

  33. Boarder MR, Marriott DB: Endothelin-1 stimulation of noradrenaline and adrenaline release from adrenal chromaffin cells.Biochemical Pharmacology. 1991,41:521–526.

    Article  PubMed  CAS  Google Scholar 

  34. Larkin KT, Zayfert C: Anger management training with mild essential hypertensive patients.Journal of Behavioral Medicine. 1996,19:415–433.

    Article  PubMed  CAS  Google Scholar 

  35. Linden W, Lenz JW, Con AH: Individualized stress management for primary hypertension: A randomized trial.Archives of Internal Medicine. 2001,161:1071–1080.

    Article  PubMed  CAS  Google Scholar 

  36. Steer CJ, Kren BT: Gene therapy and CVD: How near are we?Atherosclerosis Supplements. 2004,5:33–42.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Psychiatry, Department of Pediatrics, and Georgia Prevention Institute, Medical College of Georgia, USA

    Kristen M. Rabineau M.A., Frank A. Treiber Ph.D., Joseph Poole M.S. & David Ludwig Ph.D.

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  1. Kristen M. Rabineau M.A.
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  2. Frank A. Treiber Ph.D.
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  3. Joseph Poole M.S.
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  4. David Ludwig Ph.D.
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Correspondence to Frank A. Treiber Ph.D..

Additional information

This article was supported by grant P01 HL69999 from the National Heart, Lung, and Blood Institute.

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Rabineau, K.M., Treiber, F.A., Poole, J. et al. Interactive effects of anger expression and ET-1 Lys198Asn polymorphism on vasoconstriction reactivity to behavioral stress. ann. behav. med. 30, 85–89 (2005). https://doi.org/10.1207/s15324796abm3001_10

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  • DOI: https://doi.org/10.1207/s15324796abm3001_10

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