Changes in physical symptoms during the menopause transition



This article analyzes physical symptoms experienced by mid-age Australian women in different stages of the menopause transition. A total of 8,623 women, aged 45 to 50 years in 1996, who participated the mid-age cohort of the Australian Longitudinal Study on Women’s Health, completed Survey 1 in 1996 and Survey 2 in 1998. Women were assignedto 1 of6menopause groups according totheir menopausal status at Surveys 1 and 2, and compared on symptoms experienced at Surveys 1 and 2, adjusted for lifestyle, behavioral and demographic factors. At Survey 1, the most commonly reported symptoms were headaches, back pain, stiff joints, tiredness, and difficulty sleeping. Perimenopausal women were more likely than premenopausal or postmenopausal women to report these symptoms. Hot flushes and night sweats were more common among postmenopausal women. Compared with those who remained premenopausal, women who were in the early stages of menopause or perimenopausal were more likely to report tiredness, stiff joints, difficulty sleeping, and hot flushes at Survey 2. Women who remained perimenopausal were also more likely to report back pain and leaking urine. Compared with premenopausal women, odds ratios for night sweats increased for women in consecutive stages of the menopause transition and remained high in the postmenopausal women.

Key words

cohort study women menopausal symptoms physical symptoms 


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  1. Avis, N., Brambilla, D., McKinlay, S. M., & Vass, K. (1994). A longitudinal analysis of the association between menopause and depression—results from the Massachusetts women’s health study.Annals of Epidemiology, 4, 214–220.PubMedCrossRefGoogle Scholar
  2. Avis, N., Kaufert, P., Lock, M., McKinlay, S. M., & Vass, K. (1993). The evolution of menopausal symptoms.Balliere’s Clinical Endocrinology and Metabolism’International Practice and Research, 7(1), 17–32.Google Scholar
  3. Avis, N. E., & McKinlay, S. M. (1990). Health care utilisation among mid-aged women.Annals of the New York Academy of Sciences, 592, 228–238.PubMedCrossRefGoogle Scholar
  4. Brown, W. J., & Bauman, A. (2000). Comparison of estimates of population levels of physical activity using two measures.Australian and New Zealand Journal of Public Health, 24, 520–525.PubMedCrossRefGoogle Scholar
  5. Brown, W. J., Bryson, L., Byles, J. E., Dobson, A. J.,Lee, C., Mishra, G., & Schofield, M. (1998). Women’s Health Australia: Recruitment for a national longitudinal cohort study.Women and Health, 28(1), 23–40.Google Scholar
  6. Brown, W. J., Mishra, G.,; & Lee, C. (2000). Leisure time physical activity in Australian women: Relationship with well-beingand symptoms.Research Quarterly for Exercise and Sport, 71(3) 206–216.PubMedGoogle Scholar
  7. Collins, A., & Landgren, B-M. (1995). Reproductive health, use of oestrogen and experience of symptoms in peri-menopausal women: A population-based study.Maturitas, 20, 101–111.CrossRefGoogle Scholar
  8. Cooper, G. S., Baird, D. D., & Darden, F. R.(2001). Measures ofmenopausal status in relationto demographic, reproductive and behavioral characteristics in a population-based study of women aged 35–49 years.American Journal of Epidemiology, 153, 1159–1165.PubMedCrossRefGoogle Scholar
  9. Dennerstein, L. (1996). Well-being, symptoms and the menopausal transition.Maturitas, 23, 147–157.PubMedCrossRefGoogle Scholar
  10. Dennerstein, L., Smith, A. M., Morse, C., Burger, H., Green, A., Hopper, J., & Ryan, M. (1993). Menopausal symptoms in Australian women.Medical Journal of Australia, 159, 232–236.PubMedGoogle Scholar
  11. Department of Primary Industries and Energy & Department of Human Services and Health. (1994).Rural, remote and metropolitan areas classification: 1991 census edition. Canberra: Australian Government Publishing Service.Google Scholar
  12. Dudley, E. C., Hopper, J. L., Taffe, J., Guthrie, R., Burger, H. G., & Dennerstein, L. (1998). Using longitudinal data to define the perimenopausebymenstrual cycle characteristics.Climacteric, 1, 18–25.PubMedCrossRefGoogle Scholar
  13. Garamszegi, C., Dennerstein, L., Dudley, E., Guthrie, J., Ryan, M., & Burger, H. (1998). Menopausal status: Subjectively and objectively defined.Journal of Psychosomatic Obstetrics and Gynaecology, 19, 165–173.PubMedCrossRefGoogle Scholar
  14. Greer, G. (1991).The change, women, ageing and the menopause. London: Hamish Hamilton.Google Scholar
  15. Kaufert, P. (1984). Women and their healthin the middle years:A Manitoba project.Social Science and Medicine, 3, 279–281.Google Scholar
  16. Kaufert, P. A., Gilbert, P., & Tate, R. (1992). The Manitoba project: A re-examiningof the link between menopause and depression.Maturitas, 14, 143–156.PubMedCrossRefGoogle Scholar
  17. Kronenberg, F. (1990). Hot flushes: Epidemiology and physiology. Multidisciplinary perspectives of menopause.Annals of the New York Academy of Sciences, 592, 52–86.PubMedCrossRefGoogle Scholar
  18. Matthews, K. A., Wing, R. R., Kuller, L. H., Meilahn E. N., Kesley S. F., Costello, E. J. & Caggiula A. W., (1990). Influencesofnatural menopauseonpsychological characteristics and symptomsinmiddle-aged healthy women.Journal of Consulting and Clinical Psychology, 58, 345–351.PubMedCrossRefGoogle Scholar
  19. Matthews, K. A., Wing, R. R., Kuller, L. H., Meilahn, E. N. & Platinga, (1994). Influence of the perimenopause on cardiovascular risk factors and symptoms in middle-aged healthy women.Archives of Internal Medicine, 154, 2349–2355.PubMedCrossRefGoogle Scholar
  20. McKinlay, S. M., Brambilla, D. J., & Posner, J. G. (1992). The normal menopause transition.Maturitas, 14, 103–115.PubMedCrossRefGoogle Scholar
  21. Miller, Y. D., Brown,W. J., Smith, N., & Chiarelli, P. (2001). Managing urinary incontinence across the lifespan. Manuscript submitted for publication.Google Scholar
  22. Mishra, G. D., Brown,W. J., & Dobson A. J. (2001).Physical and mental health: Changes during menopause transition. Manuscript submitted for publication.Google Scholar
  23. Morse C. A., Dudley, E., Guthrie, J., & Dennerstein, L. (1998). Relationships between premenstrual complaints and perimenopausal experiences.Journal of Psychosomatic Obstetrics and Gynaecology, 19, 182–191.PubMedCrossRefGoogle Scholar
  24. Oldenhave, A., Jaszmann, J. B., Haspels, A. A., & Everaerd, W. T. (1993). Impact of climacteric on well-being: A survey based on 5213 women 39–60 years old.American Journal of Obstetrics and Gynaecology, 168, 772–780.Google Scholar
  25. Patterson, A. J., Brown, W. J., Powers, J. R., & Roberts, D. C. K. (2000). Iron deficiency, general health and fatigue: Results from the Australian Longitudinal Studyof Women’s Health.Quality of Life Research, 9, 491–497.PubMedCrossRefGoogle Scholar
  26. SAS Institute Inc. (1989).SAS/STAT User’s guide, Version 6, (Vol. 2, 4th ed.). Cary, NC: Author.Google Scholar
  27. Utian, W. H. (1987). Overview on menopause.American Journal of Obstetrics and Gynecology, 156, 1280–1283.PubMedGoogle Scholar
  28. Ware, J. E., Snow, K. K., Kosinski, M., & Gandek, B. (1993).SF–36 Health survey manual and interpretation guide. Boston: The Health Institute, New England Medical Centre.Google Scholar

Copyright information

© International Society of Behavioral Medicine 2002

Authors and Affiliations

  • Wendy J. Brown
    • 1
  • Gita D. Mishra
    • 2
  • Annette Dobson
    • 3
  1. 1.School of Human Movement StudiesUniversity of QueenslandBrisbaneAustralia
  2. 2.MRC Human Nutrition LaboratoryCambridgeUK
  3. 3.School of Population HealthUniversity of QueenslandAustralia

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