Fig. 6

Mass spectrometry (MS) and bioinformatics-based proteomic analysis of EV cargo. a Venn diagram based on the proteins identified by MS hits. b Venn diagram of all proteins identified compared with proteins annotated in the Vesiclepedia database. c Gene enrichment analysis for ‘Cellular component’ was performed based on the MS hits identified from each EV separation method. d Pairwise comparison diagram showing the similarity between the proteome contents of the different EV separation methods and the identified EV-related proteins from the Vesiclepedia database