Brazil nuts are rich in important nutrients including unsaturated fatty acids and fiber and are the highest known food source of selenium. Selenium has exhibited a multitude of health benefits including increased antioxidant capacity, improvement of lipid profiles, insulin and glucose responses, and elevation of mood. The purpose of the present study was to determine the effects of Brazil nut consumption on postprandial satiety, glucose, insulin, antioxidant activity, and anxiety in healthy subjects.
In a crossover design with two trials, 22 healthy adults (age 25 ± 4.94 years, BMI 22.3 ± 3.29 kg/m2) consumed pretzels (36 g) and isocaloric, sodium-matched Brazil nuts (20 g), separated by a 48-h washout period. A visual analogue scale measured satiety at baseline, 20 and 40 min after snack consumption. Anxiety (via modified STAI), blood glucose, insulin, and antioxidant levels were measured at baseline and 40 min.
Both the Brazil nuts and pretzels increased satiety with greater satiety in Brazil nuts compared to pretzels (P = 0.049). Each snack also decreased anxiety (P = 0.020) from baseline to 40 min post-consumption with no significant differences between the two trials. Pretzel consumption caused a significant increase in blood glucose and insulin (P < 0.001) at 40 min post-consumption compared to baseline, while Brazil nut consumption did not significantly increase either level.
Brazil nut consumption improved postprandial satiety and stabilized glucose and insulin responses compared to baseline, which warrants further studies on reducing overall food intake and preventing cardiovascular disease, diabetes, and weight gain.
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The data that support the findings of this study are available on request from the corresponding author (firstname.lastname@example.org).
Body mass index
Enzyme-linked immunosorbent assay
State-Trait Anxiety Inventory
Visual analogue scale
Hull S, Re R, Chambers L, Echaniz A, Wickham M. A mid-morning snack of almonds generates satiety and appropriate adjustment of subsequent food intake in healthy women. Eur J Nutr. 2015;54(5):803–10.
Jaceldo-Siegl K, Sabaté J, Batech M, Fraser GE. Influence of body mass index and serum lipids on the cholesterol-lowering effects of almonds in free-living individuals. Nutr Metab Cardiovasc Dis. 2011;21(1):S7–S13.
Hshieh T, Petrone A, Gaziano J, Djoussé L. Nut consumption and risk of mortality in the Physicians' health study. Am J Clin Nutr. 2015;101(2):407–12.
Del Gobbo L, Falk M, Feldman R, Lewis K, Mozaffarian D. Effects of tree nuts on blood lipids, apolipoproteins, and blood pressure: systematic review, meta-analysis, and dose-response of 61 controlled intervention trials. Am J Clin Nutr. 2015;102(6):1347–56.
Sabate J. Nut consumption, vegetarian diets, ischemic heart disease risk, and all-cause mortality: evidence from epidemiologic studies. Am J Clin Nutr. 1999;70(3):500S–3S.
Yang J. Brazil nuts and associated health benefits: a review. LWT Food Sci Technol. 2009;42(10):1573–80.
Duntas L. Selenium and the thyroid: a close-knit connection. J Clin Endocrinol Metab. 2010;95(12):5180–8.
Wang N, Tan H, Li S, Xu Y, Guo W, Feng Y. Supplementation of micronutrient selenium in metabolic diseases: its role as an antioxidant. Oxid Med Cell Longev. 2017;2017:7478523. https://doi.org/10.1155/2017/7478523.
Carvalho R, Huguenin G, Luiz R, Moreira A, Oliveira G, Rosa G. Intake of partially defatted Brazil nut flour reduces serum cholesterol in hypercholesterolemic patients: a randomized controlled trial. Nutr J. 2015;14:59. https://doi.org/10.1186/s12937-015-0036-x.
Benton D, Cook R. Selenium supplementation improves mood in a double-blind crossover trial. Psychopharmacology. 1990;102(4):549–50.
Cardoso BR, Duarte GBS, Reis BZ, Cozzolino SMF. Brazil nuts: nutritional composition, health benefits and safety aspects. Food Res Int. 2017;100(2):9–18.
Kornsteiner M, Wagner KH, Elmadfa I. Tocopherols and total phenolics in 10 different nut types. Food Chem. 2006;98(2):381–7.
Thomson C, Chisholm A, Mclachlan S, Campbell J. Brazil nuts: an effective way to improve selenium status. Am J Clin Nutr. 2008;87(2):379–84.
Llewellyn C, Trzaskowski M, Van Jaarsveld C, Plomin R, Wardle J. Satiety mechanisms in genetic risk of obesity. JAMA Pediatr. 2014;168(4):338–44.
Maranhão P, Kraemer-Aguiar L, De Oliveira C, Kuschnir M, Vieira Y, Souza M, et al. Brazil nuts intake improves lipid profile, oxidative stress and microvascular function in obese adolescents: a randomized controlled trial. Nutr Metab. 2011;8(1):32.
Viguiliouk E, Kendall CWC, Mejia SB, Cozma AI, Ha V, Mirrahimi A, et al. Effect of tree nuts on glycemic control in diabetes: a systematic review and meta-analysis of randomized controlled dietary trials. PLoS One. 2014;9(7):E103376.
Donadio JLS, Rogero MM, Guerra-Shinohara EM, Desmarchelier C, Borel P, Cozzolino SMF. SEPP1 polymorphisms modulate serum glucose and lipid response to Brazil nut supplementation. Eur J Nutr. 2018;57(5):1873–82.
United States Department of Agriculture Supertracker. https://www.choosemyplate.gov/tools-supertracker [Accessed April 9, 2018].
Flint A, Raben A, Blundell JE, Astrup A. Reproducibility, power and validity of visual analogue scales in assessment of appetite sensations in single test meal studies. Int J Obes. 2000;24:38–48.
Marteau TM, Bekker H. The development of a six-item short-form of the state scale of the Spielberger state-trait anxiety inventory (STAI). Br J Clin Psychol. 1992;31(3):301–6.
McKay DL, Eliasziw M, Chen CYO, Blumberg JB. A pecan-rich diet improves cardiometabolic risk factors in overweight and obese adults: a randomized controlled trial. Nutrients. 2018;10(3):339. https://doi.org/10.3390/nu10030339.
Gulati S, Misra A, Pandey RM, Bhatt SP, Saluja S. Effects of pistachio nuts on body composition, metabolic, inflammatory and oxidative stress parameters in Asian Indians with metabolic syndrome: a 24-wk, randomized control trial. Nutrition. 2014;30(2):192–7. https://doi.org/10.1016/j.nut.2013.08.005.
Aronis KN, Vamvini MT, Chamberland JP, Sweeney LL, Brennan AM, Magkos F, et al. Short-term walnut consumption increases circulating total adiponectin and apolipoprotein a concentrations, but does not affect markers of inflammation or vascular injury in obese humans with the metabolic syndrome: data from a double-blinded, randomized, placebo-controlled study. Metab Clin Exp. 2012;61(4):577–82. https://doi.org/10.1016/j.metabol.2011.09.008.
Kendall CWC, West SG, Augustin LS, Esfahani A, Vidgen E, Bashyam B, et al. Acute effects of pistachio consumption on glucose and insulin, satiety hormones and endothelial function in the metabolic syndrome. Eur J Nutr. 2014;68(3):370–5. https://doi.org/10.1038/ejcn.2013.275.
Pasman WJ, Heimerikx J, Rubingh CM, et al. The effect of Korean pine nut oil on in vitro CCK release, on appetite sensations and on gut hormones in post-menopausal overweight women. Lipids Health Dis. 2008;7:10. https://doi.org/10.1186/1476-511X-7-10.
Wang J, Um P, Dickerman BA, Liu J. Zinc, magnesium, selenium and depression: a review of the evidence, potential mechanisms and implications. Nutrients. 2018;10(5):584. https://doi.org/10.3390/nu10050584.
Martin FPJ, Antille N, Rezzi S, Kochhar S. Everyday eating experiences of chocolate and non-chocolate snacks impact postprandial anxiety, energy, and emotional states. Nutrients. 2012;4(6):554–67. https://doi.org/10.3390/nu4060554.
Leidy HJ, Todd CB, Zino AZ, Immel JE, Mukherjea R, Shafer RS, et al. Consuming high-protein soy snacks affects appetite control, satiety, and diet quality in young people and influences select aspects of mood and cognition. J Nutr. 2015;145(7):1614–22. https://doi.org/10.3945/jn.115.212092.
Widenhorn-Muller K, Hille K, Klenk J, Weiland U. Influence of having breakfast on cognitive performance and mood in 13- to 20-year-old high school students: results of a crossover trial. Pediatrics. 2008;122(2):279–84. https://doi.org/10.1542/peds.2007-0944.
John J, Shahidi F. Phenolic compounds and antioxidant activity of Brazil nut (Bertholletia excelsa). J Funct Foods. 2010;2(3):196–209. https://doi.org/10.1016/j.jff.2010.04.008.
Stockler-Pinto MB, Mafra D, Moraes C, et al. A follow-up study of the chronic kidney disease patients treated with Brazil nut: focus on inflammation and oxidative stress. Biol Trace Elem Res. 2015;163(1–2):67–72.
The authors acknowledge the contributions of all participants for the study and the students of N302 L Advanced Nutrition Laboratory class students at San Diego State University for their help on sample collection.
This study was funded by the American Heart Association (16GRNT31360007).
The authors declare that they have no conflict(s) of interest.
The study protocol was approved by the San Diego State University Institutional Review Board for the protection of human subjects, and all participants provided informed written consent prior to their participation (Clinicaltrials.gov, NCT03956602).
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All authors are in agreement with the manuscript and declare that the content has not been published elsewhere except conference abstract.
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Rosenstock, A., Connolly, M., Weller, R. et al. Brazil nut consumption promotes satiety without increasing blood glucose and insulin responses in healthy adults. Nutrire 45, 3 (2020). https://doi.org/10.1186/s41110-019-0108-3
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